Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-3702-00803
Entry Name
UniProt Accession
Theoretical PI
4.89
Molecular Weight
25809.38
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Calcineurin B-like protein 2
Protein Synonyms/Alias
SOS3-like calcium-binding protein 1;
Gene Name
CBL2
Gene Synonyms/Alias
SCABP1; At5g55990; MDA7.3;
Created Date
21-DEC-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
4
Canonical
****MSQCVDGIKHL
[1]
S-Palmitoylation
12
Canonical
VDGIKHLCTSVLGCF
[1]
S-Palmitoylation
18
Canonical
LCTSVLGCFDLDLYK
[1]
S-Palmitoylation
Organism
Arabidopsis thaliana (Mouse-ear cress)
NCBI Taxa ID
3702
Reference
[1] Batistič O, Rehers M, Akerman A, Schlücking K, Steinhorst L, Yalovsky S, KudlaJ. S-acylation-dependent association of the calcium sensor CBL2 with the vacuolarmembrane is essential for proper abscisic acid responses. Cell Res. 2012Jul;22(7):1155-68. doi: 10.1038/cr.2012.71. Epub 2012 May 1.[PMID:22547024]
Functional Description
Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Binds four calcium ions per subunit. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Mediates the inactivation of the proton pump AHA2 by CIPK11. Probably involved in regulating signaling responses to abscisic acid.
Sequence Annotation
Domain: 36 81 EF-hand 1.
Domain: 82 117 EF-hand 2.
Domain: 119 154 EF-hand 3.
Domain: 163 198 EF-hand 4.
Functional site: 155 155 Involved in dimerization.
Modified residue: 216 216 Phosphoserine; by CIPK11 and CIPK14.
Protein Length
226 AA.
Protein Sequence
(Canonical)
MSQCVDGIKH LCTSVLGCFD LDLYKQSGGL GDPELLARDT VFSVSEIEAL YELFKKISSA  60
VIDDGLINKE EFQLALFKTN KKESLFADRV FDLFDTKHNG ILGFEEFARA LSVFHPNAPI  120
DDKIHFSFQL YDLKQQGFIE RQEVKQMVVA TLAESGMNLK DTVIEDIIDK TFEEADTKHD  180
GKIDKEEWRS LVLRHPSLLK NMTLQYLKDI TTTFPSFVFH SQVEDT                 226
FASTA
(Canonical)
>LipidDB-3702-00803|Q8LAS7
MSQCVDGIKHLCTSVLGCFDLDLYKQSGGLGDPELLARDTVFSVSEIEALYELFKKISSA
VIDDGLINKEEFQLALFKTNKKESLFADRVFDLFDTKHNGILGFEEFARALSVFHPNAPI
DDKIHFSFQLYDLKQQGFIERQEVKQMVVATLAESGMNLKDTVIEDIIDKTFEEADTKHD
GKIDKEEWRSLVLRHPSLLKNMTLQYLKDITTTFPSFVFHSQVEDT
Gene Ontology
GO:0022626; C:cytosolic ribosome; IDA:TAIR
GO:0016020; C:membrane; IDA:TAIR
GO:0009705; C:plant-type vacuole membrane; IDA:TAIR
GO:0005773; C:vacuole; IDA:TAIR
GO:0005509; F:calcium ion binding; ISS:TAIR
GO:0019722; P:calcium-mediated signaling; TAS:TAIR
GO:0055075; P:potassium ion homeostasis; IMP:TAIR
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR002048; EF_hand_dom
Pfam
Pfam; PF13202; EF-hand_5;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS50222; EF_HAND_2;
PRINTS