LipidDB ID

LipidDB-3702-00348

Entry Name

UniProt Accession

Q96262; F4JUT4; Q56YV4; Q8H7H8; Q8LDH5;

Theoretical PI

4.99

Molecular Weight

24583.84

Genbank Protein ID

CAA69300.1; CAA18251.1; CAB79026.1; AEE84291.1; AEE84292.1; AEE84293.1; AEE84294.1; AAM13083.1; AAM91168.1; BAH20189.1; AAM63213.1; AAN60228.1; BAD93780.1;

Genbank Nucleotide ID

Y08061; AL022224; AL161552; CP002687; CP002687; CP002687; CP002687; AY093084; AY128768; AK317524; AY086004; AF083669; AK221216;

Protein Name

Plasma membrane-associated cation-binding protein 1

Protein Synonyms/Alias

AtPCAP1; Microtubule-destabilizing protein 25;

Gene Name

PCAP1

Gene Synonyms/Alias

MDP25; At4g20260; F1C12.180;

Created Date

31-OCT-2012

Organism

Arabidopsis thaliana (Mouse-ear cress)

NCBI Taxa ID

3702

Reference

[1] Nagasaki N, Tomioka R, Maeshima M. A hydrophilic cation-binding protein ofArabidopsis thaliana, AtPCaP1, is localized to plasma membrane viaN-myristoylation and interacts with calmodulin and the phosphatidylinositolphosphates PtdIns(3,4,5)P(3) and PtdIns(3,5)P(2). FEBS J. 2008May;275(9):2267-82. doi: 10.1111/j.1742-4658.2008.06379.x. Epub 2008 Apr 3.[PMID:18397324]

Functional Description

May be involved in intracellular signaling through interaction with PtdInsPs and calmodulin (CaM); may keep PtdInsPs attached to the plasma membrane until Ca(2+)-CaM reaches a competitive concentration subsequent to an increase triggered by a stimulus, thus leading to PtdInsPs release and subsequent activation of InsPs-dependent signaling cascade. Interacts competitively at the N-terminus with calcium ions and CaM (in a calcium-dependent manner), and with the phosphatidylinositol phosphates PtdIns(3,4,5)P(3), PtdIns(3,4)P(2), PtdIns(4,5)P(2) and PtdIns(3,5)P(2). Binds also weakly to PtdIns(3)P, PtdIns(4)P and PtdIns(5)P. Negative regulator of hypocotyl cell elongation by destabilizing cortical microtubules in a calcium-dependent manner. Binds directly to and destabilized microtubules to enhance microtubule depolymerization when cytoplasmic calcium increases. In case of Turnip mosaic virus (TuMV) infection, confers sensitivity by promoting viral cell-to-cell movement through interaction with viral P3N-PIPO.

Sequence Annotation

Modified residue: 177 177 Phosphothreonine.

Protein Length

225 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB
GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0009506; C:plasmodesma; IDA:UniProtKB
GO:0005509; F:calcium ion binding; IDA:UniProtKB
GO:0005516; F:calmodulin binding; IDA:UniProtKB
GO:0005507; F:copper ion binding; IDA:UniProtKB
GO:0008017; F:microtubule binding; IDA:UniProtKB
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB
GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:UniProtKB
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB
GO:0071280; P:cellular response to copper ion; IEP:UniProtKB
GO:0071281; P:cellular response to iron ion; IEP:UniProtKB
GO:0071286; P:cellular response to magnesium ion; IEP:UniProtKB
GO:0010350; P:cellular response to magnesium starvation; IEP:UniProtKB
GO:0071325; P:cellular response to mannitol stimulus; IEP:UniProtKB
GO:0071219; P:cellular response to molecule of bacterial origin; IEP:UniProtKB
GO:0035865; P:cellular response to potassium ion; IEP:UniProtKB
GO:0071472; P:cellular response to salt stress; IEP:UniProtKB
GO:0072709; P:cellular response to sorbitol; IEP:UniProtKB
GO:0043622; P:cortical microtubule organization; IDA:UniProtKB
GO:0006499; P:N-terminal protein myristoylation; IMP:UniProtKB
GO:0051511; P:negative regulation of unidimensional cell growth; IMP:UniProtKB
GO:0031117; P:positive regulation of microtubule depolymerization; IDA:UniProtKB
GO:0009414; P:response to water deprivation; IEP:UniProtKB
GO:0016032; P:viral process; IEA:UniProtKB-KW

Interpro

InterPro; IPR008469; DREPP

Pfam

Pfam; PF05558; DREPP;

SMART

PROSITE

PRINTS