| Tag |
Content |
LipidDB ID |
LipidDB-3702-00282 |
Entry Name |
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UniProt Accession |
|
Theoretical PI |
6.08 |
Molecular Weight |
66122.31 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Phosphoinositide phospholipase C 2 |
Protein Synonyms/Alias |
3.1.4.11; Phosphoinositide phospholipase PLC2; AtPLC2; PI-PLC2; |
Gene Name |
PLC2 |
Gene Synonyms/Alias |
At3g08510; T8G24.4; |
Created Date |
18-MAR-2008 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
9 | Canonical | SKQTYKVCFCFRRRF | [1] | S-Palmitoylation | 11 | Canonical | QTYKVCFCFRRRFRY | [1] | S-Palmitoylation |
|
Organism |
Arabidopsis thaliana (Mouse-ear cress) |
NCBI Taxa ID |
3702 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. At physiological calcium concentration, the preferred substrate is phosphatidylinositol 4,5-bisphosphate versus phosphatidylinositol. |
Sequence Annotation |
Domain: 26 102 EF-hand-like.
Domain: 103 248 PI-PLC X-box.
Domain: 317 433 PI-PLC Y-box.
Domain: 439 546 C2.
Active site: 118 118
Active site: 164 164
|
Protein Length |
581 AA. |
Protein Sequence
(Canonical) |
MSKQTYKVCF CFRRRFRYTA SEAPREIKTI FEKYSENGVM TVDHLHRFLI DVQKQDKATR 60
EDAQSIINSA SSLLHRNGLH LDAFFKYLFG DNNPPLALHK VHHDMDAPIS HYFIFTGHNS 120
YLTGNQLSSD CSEVPIIDAL KKGVRVIELD IWPNSNKDDI DVLHGMTLTT PVGLIKCLKA 180
IRAHAFDVSD YPVVVTLEDH LTPDLQSKVA EMVTEIFGEI LFTPPVGESL KEFPSPNSLK 240
RRIIISTKPP KEYKEGKDVE VVQKGKDLGD EEVWGREVPS FIQRNKSEAK DDLDGNDDDD 300
DDDDEDKSKI NAPPQYKHLI AIHAGKPKGG ITECLKVDPD KVRRLSLSEE QLEKAAEKYA 360
KQIVRFTQHN LLRIYPKGTR VTSSNYNPLV GWSHGAQMVA FNMQGYGRSL WLMQGMFRAN 420
GGCGYIKKPD LLLKSGSDSD IFDPKATLPV KTTLRVTVYM GEGWYFDFRH THFDQYSPPD 480
FYTRVGIAGV PGDTVMKKTK TLEDNWIPAW DEVFEFPLTV PELALLRLEV HEYDMSEKDD 540
FGGQTCLPVW ELSEGIRAFP LHSRKGEKYK SVKLLVKVEF V 581
|
FASTA
(Canonical) |
>LipidDB-3702-00282|Q39033
MSKQTYKVCFCFRRRFRYTASEAPREIKTIFEKYSENGVMTVDHLHRFLIDVQKQDKATR
EDAQSIINSASSLLHRNGLHLDAFFKYLFGDNNPPLALHKVHHDMDAPISHYFIFTGHNS
YLTGNQLSSDCSEVPIIDALKKGVRVIELDIWPNSNKDDIDVLHGMTLTTPVGLIKCLKA
IRAHAFDVSDYPVVVTLEDHLTPDLQSKVAEMVTEIFGEILFTPPVGESLKEFPSPNSLK
RRIIISTKPPKEYKEGKDVEVVQKGKDLGDEEVWGREVPSFIQRNKSEAKDDLDGNDDDD
DDDDEDKSKINAPPQYKHLIAIHAGKPKGGITECLKVDPDKVRRLSLSEEQLEKAAEKYA
KQIVRFTQHNLLRIYPKGTRVTSSNYNPLVGWSHGAQMVAFNMQGYGRSLWLMQGMFRAN
GGCGYIKKPDLLLKSGSDSDIFDPKATLPVKTTLRVTVYMGEGWYFDFRHTHFDQYSPPD
FYTRVGIAGVPGDTVMKKTKTLEDNWIPAWDEVFEFPLTVPELALLRLEVHEYDMSEKDD
FGGQTCLPVWELSEGIRAFPLHSRKGEKYKSVKLLVKVEFV
|
Gene Ontology |
GO:0005886; C:plasma membrane; IDA:TAIR GO:0005509; F:calcium ion binding; IEA:InterPro GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW GO:0035556; P:intracellular signal transduction; IEA:InterPro GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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