LipidDB ID

LipidDB-3702-00134

Entry Name

UniProt Accession

Q9LTB8;

Theoretical PI

4.58

Molecular Weight

24531.84

Genbank Protein ID

AAL10301.1; BAA98105.1; AED95471.1; BAB69895.1; AAO22803.1; AAO42452.1;

Genbank Nucleotide ID

AF411958; AB025609; CP002688; AB060590; BT002995; BT004458;

Protein Name

Calcineurin B-like protein 9

Protein Synonyms/Alias

Gene Name

CBL9

Gene Synonyms/Alias

At5g47100; K14A3.5;

Created Date

21-DEC-2004

Organism

Arabidopsis thaliana (Mouse-ear cress)

NCBI Taxa ID

3702

Reference

[1] Batistic O, Sorek N, Schültke S, Yalovsky S, Kudla J. Dual fatty acylmodification determines the localization and plasma membrane targeting ofCBL/CIPK Ca2+ signaling complexes in Arabidopsis. Plant Cell. 2008May;20(5):1346-62. doi: 10.1105/tpc.108.058123. Epub 2008 May 23.[PMID:18502848]

Functional Description

Acts as a calcium sensor involved in abscisic acid (ABA) signaling and stress-induced ABA biosynthesis pathways. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine- threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a negative regulator of stress and ABA responses. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF. The CBL9/CIPK3 complex acts in the regulation of abscisic acid response in seed germination.

Sequence Annotation

Domain: 31 66 EF-hand 1.
Domain: 67 102 EF-hand 2.
Domain: 104 139 EF-hand 3.
Domain: 148 183 EF-hand 4.
Functional site: 140 140 Involved in dimerization.
Modified residue: 201 201 Phosphoserine; by CIPK23.

Protein Length

213 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:TAIR
GO:0005886; C:plasma membrane; IDA:TAIR
GO:0005509; F:calcium ion binding; ISS:TAIR
GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW
GO:0010107; P:potassium ion import; IGI:TAIR
GO:0009414; P:response to water deprivation; IMP:TAIR
GO:0010118; P:stomatal movement; IGI:TAIR

Interpro

InterPro; IPR015757; Calcineur_B
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom

Pfam

Pfam; PF13499; EF-hand_7;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS