| Tag |
Content |
LipidDB ID |
LipidDB-367110-01122 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
7.82 |
Molecular Weight |
61522.15 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Cytochrome c oxidase subunit 1 |
Protein Synonyms/Alias |
1.9.3.1; Cytochrome c oxidase polypeptide I; |
Gene Name |
cox-1 |
Gene Synonyms/Alias |
coi; cox1; NCM025; NCU16016; |
Created Date |
23-OCT-1986 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
324 | Canonical | IAVPTGIKIFSWLAT | [1] | N-Myristoylation |
|
Organism |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DS 1257 / FGSC 987) |
NCBI Taxa ID |
367110 |
Reference |
[1] Vassilev AO, Plesofsky-Vig N, Brambl R. Cytochrome c oxidase in Neurosporacrassa contains myristic acid covalently linked to subunit 1. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8680-4.[ PMID:7567996]
|
Functional Description |
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. |
Sequence Annotation |
Transmembrane: 22 42 Helical.
Transmembrane: 69 89 Helical.
Transmembrane: 106 126 Helical.
Transmembrane: 151 171 Helical.
Transmembrane: 187 207 Helical.
Transmembrane: 240 260 Helical.
Transmembrane: 272 292 Helical.
Transmembrane: 310 330 Helical.
Transmembrane: 343 363 Helical.
Transmembrane: 378 398 Helical.
Transmembrane: 418 438 Helical.
Transmembrane: 457 477 Helical.
Metal binding site: 67 67 Iron (heme A axial ligand).
Metal binding site: 246 246 Copper B.
Metal binding site: 250 250 Copper B.
Metal binding site: 295 295 Copper B.
Metal binding site: 296 296 Copper B.
Metal binding site: 381 381 Iron (heme A3 axial ligand).
Metal binding site: 383 383 Iron (heme A axial ligand).
|
Protein Length |
557 AA. |
Protein Sequence
(Canonical) |
MSSISIWTER WFLSTNAKDI GVLYLIFALF SGLLGTAFSV LIRMELSGPG VQYIADNQLY 60
NAIITAHAIL MIFFMVMPAL IGGFGNFLLP LLVGGPDMAF PRLNNISFWL LPPSLLLLVF 120
SACIEGGAGT GWTIYPPLSG VQSHSGPSVD LAIFALHLSG VSSLLGSINF ITTIVNMRTP 180
GIRLHKLALF GWAVVITAVL LLLSLPVLAG AITMLLTDRN FNTSFFETAG GGDPILFQHL 240
FWFFGHPEVY ILIIPGFGII STTISAYSNK SVFGYIGMVY AMMSIGILGF IVWSHHMYTV 300
GLDVDTRAYF TAATLIIAVP TGIKIFSWLA TCYGGSIRLT PSMLFALGFV FMFTIGGLSG 360
VVLANASLDI AFHDTYYVVA HFHYVLSMGA VFAMFSGWYH WVPKILGLNY NMVLSKAQFW 420
LLFIGVNLTF FPQHFLGLQG MPRRISDYPD AFSGWNLISS FGSIVSVVAS WLFLYIVYIQ 480
LVQGEYAGRY PWSIPQFYTD SLRALLNRSY PSLEWSISSP PKPHSFVSLP LQSSSFFLSF 540
FRLSSYGEQK EISGRQN 557
|
FASTA
(Canonical) |
>LipidDB-367110-01122|P03945
MSSISIWTERWFLSTNAKDIGVLYLIFALFSGLLGTAFSVLIRMELSGPGVQYIADNQLY
NAIITAHAILMIFFMVMPALIGGFGNFLLPLLVGGPDMAFPRLNNISFWLLPPSLLLLVF
SACIEGGAGTGWTIYPPLSGVQSHSGPSVDLAIFALHLSGVSSLLGSINFITTIVNMRTP
GIRLHKLALFGWAVVITAVLLLLSLPVLAGAITMLLTDRNFNTSFFETAGGGDPILFQHL
FWFFGHPEVYILIIPGFGIISTTISAYSNKSVFGYIGMVYAMMSIGILGFIVWSHHMYTV
GLDVDTRAYFTAATLIIAVPTGIKIFSWLATCYGGSIRLTPSMLFALGFVFMFTIGGLSG
VVLANASLDIAFHDTYYVVAHFHYVLSMGAVFAMFSGWYHWVPKILGLNYNMVLSKAQFW
LLFIGVNLTFFPQHFLGLQGMPRRISDYPDAFSGWNLISSFGSIVSVVASWLFLYIVYIQ
LVQGEYAGRYPWSIPQFYTDSLRALLNRSYPSLEWSISSPPKPHSFVSLPLQSSSFFLSF
FRLSSYGEQKEISGRQN
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW GO:0070469; C:respiratory chain; IEA:UniProtKB-KW GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC GO:0020037; F:heme binding; IEA:InterPro GO:0005506; F:iron ion binding; IEA:InterPro GO:0009060; P:aerobic respiration; IEA:InterPro GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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