| Tag |
Content |
LipidDB ID |
LipidDB-36329-01444 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.76 |
Molecular Weight |
53593.81 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Isocitrate dehydrogenase [NADP] |
Protein Synonyms/Alias |
1.1.1.42; |
Gene Name |
|
Gene Synonyms/Alias |
PF13_0242; |
Created Date |
01-MAR-2003 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
20 | Canonical | LQFMSKRCIQSKAAF | [1] | S-Palmitoylation |
|
Organism |
Plasmodium falciparum (isolate 3D7) |
NCBI Taxa ID |
36329 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
|
Sequence Annotation |
Nucleotide-binding: 104 106 NADP.
Nucleotide-binding: 338 343 NADP.
Region: 123 129 Substrate binding.
Metal binding site: 280 280 Magnesium or manganese.
Metal binding site: 303 303 Magnesium or manganese.
Binding site: 106 106 Substrate.
Binding site: 111 111 NADP.
Binding site: 138 138 Substrate.
Binding site: 161 161 Substrate.
Binding site: 288 288 NADP.
Binding site: 356 356 NADP; via amide nitrogen and carbonyloxygen.
Functional site: 168 168 Critical for catalysis.
Functional site: 240 240 Critical for catalysis.
|
Protein Length |
468 AA. |
Protein Sequence
(Canonical) |
MGKHIRILKN QYLQFMSKRC IQSKAAFNIC GKINVENPIV ELDGDEMTRI IWKDIKEKLI 60
LPYVNLKIKY FDLSIENRDK TNDQVTIEAA EEIKKTSVGI KCATITPDAA RVKEFNLKEM 120
WKSPNGTIRN ILDGTVFRTP ILIKNIPKLV PNWKKPIVIG RHAYADQYKQ KSLKIEKSGK 180
FEIVFTPDDN SQVLRETVFH FKSPGVCLGM YNTEESIRNF ALSCFQYALD LKMPVYMSTK 240
STILKIYDGL FKDIFDEIYE KQFKKSFEQH NLWYEHKLID DMVAQVLKSE GGFLWACKNY 300
DGDIQSDAVA QGYGSLGLMS SVLLCPDGVT CVSEAAHGTV TRHYRAYQKG EKTSTNPIAS 360
IFAWTKGLEH RAKLDKNDNL KQFCYALEKA CIETVEDGLM SKDLAGCIKG IKNVTEKDYI 420
FTQDLINAIN EKLKLKILQN QSKNDPQATS YKLKNDNWNF YAPQEHST 468
|
FASTA
(Canonical) |
>LipidDB-36329-01444|Q8I6T2
MGKHIRILKNQYLQFMSKRCIQSKAAFNICGKINVENPIVELDGDEMTRIIWKDIKEKLI
LPYVNLKIKYFDLSIENRDKTNDQVTIEAAEEIKKTSVGIKCATITPDAARVKEFNLKEM
WKSPNGTIRNILDGTVFRTPILIKNIPKLVPNWKKPIVIGRHAYADQYKQKSLKIEKSGK
FEIVFTPDDNSQVLRETVFHFKSPGVCLGMYNTEESIRNFALSCFQYALDLKMPVYMSTK
STILKIYDGLFKDIFDEIYEKQFKKSFEQHNLWYEHKLIDDMVAQVLKSEGGFLWACKNY
DGDIQSDAVAQGYGSLGLMSSVLLCPDGVTCVSEAAHGTVTRHYRAYQKGEKTSTNPIAS
IFAWTKGLEHRAKLDKNDNLKQFCYALEKACIETVEDGLMSKDLAGCIKGIKNVTEKDYI
FTQDLINAINEKLKLKILQNQSKNDPQATSYKLKNDNWNFYAPQEHST
|
Gene Ontology |
GO:0005739; C:mitochondrion; IDA:GeneDB_Pfalciparum GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:GeneDB_Pfalciparum GO:0000287; F:magnesium ion binding; IEA:InterPro GO:0051287; F:NAD binding; IEA:InterPro GO:0006102; P:isocitrate metabolic process; ISS:GeneDB_Pfalciparum GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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