| Tag |
Content |
LipidDB ID |
LipidDB-36329-00007 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.64 |
Molecular Weight |
53838.92 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Adenosylhomocysteinase |
Protein Synonyms/Alias |
AdoHcyase; 3.3.1.1; PfSAHH; S-adenosyl-L-homocysteine hydrolase; |
Gene Name |
|
Gene Synonyms/Alias |
PFE1050w; |
Created Date |
01-OCT-1996 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
292 | Canonical | ITEIDPICAIQAVME | [1] | S-Palmitoylation |
|
Organism |
Plasmodium falciparum (isolate 3D7) |
NCBI Taxa ID |
36329 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. |
Sequence Annotation |
Nucleotide-binding: 201 203 NAD.
Nucleotide-binding: 264 269 NAD.
Nucleotide-binding: 343 345 NAD.
Binding site: 56 56 Substrate.
Binding site: 134 134 Substrate.
Binding site: 200 200 Substrate.
Binding site: 230 230 Substrate.
Binding site: 234 234 Substrate.
Binding site: 235 235 NAD.
Binding site: 287 287 NAD.
Binding site: 322 322 NAD.
Binding site: 391 391 NAD.
Functional site: 59 59 Important for nucleoside inhibitorbinding.
|
Protein Length |
479 AA. |
Protein Sequence
(Canonical) |
MVENKSKVKD ISLAPFGKMQ MEISENEMPG LMRIREEYGK DQPLKNAKIT GCLHMTVECA 60
LLIETLQKLG AQIRWCSCNI YSTADYAAAA VSTLENVTVF AWKNETLEEY WWCVESALTW 120
GDGDDNGPDM IVDDGGDATL LVHKGVEYEK LYEEKNILPD PEKAKNEEER CFLTLLKNSI 180
LKNPKKWTNI AKKIIGVSEE TTTGVLRLKK MDKQNELLFT AINVNDAVTK QKYDNVYGCR 240
HSLPDGLMRA TDFLISGKIV VICGYGDVGK GCASSMKGLG ARVYITEIDP ICAIQAVMEG 300
FNVVTLDEIV DKGDFFITCT GNVDVIKLEH LLKMKNNAVV GNIGHFDDEI QVNELFNYKG 360
IHIENVKPQV DRITLPNGNK IIVLARGRLL NLGCATGHPA FVMSFSFCNQ TFAQLDLWQN 420
KDTNKYENKV YLLPKHLDEK VALYHLKKLN ASLTELDDNQ CQFLGVNKSG PFKSNEYRY 479
|
FASTA
(Canonical) |
>LipidDB-36329-00007|P50250
MVENKSKVKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECA
LLIETLQKLGAQIRWCSCNIYSTADYAAAAVSTLENVTVFAWKNETLEEYWWCVESALTW
GDGDDNGPDMIVDDGGDATLLVHKGVEYEKLYEEKNILPDPEKAKNEEERCFLTLLKNSI
LKNPKKWTNIAKKIIGVSEETTTGVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCR
HSLPDGLMRATDFLISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEG
FNVVTLDEIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKG
IHIENVKPQVDRITLPNGNKIIVLARGRLLNLGCATGHPAFVMSFSFCNQTFAQLDLWQN
KDTNKYENKVYLLPKHLDEKVALYHLKKLNASLTELDDNQCQFLGVNKSGPFKSNEYRY
|
Gene Ontology |
GO:0004013; F:adenosylhomocysteinase activity; TAS:GeneDB_Pfalciparum GO:0006730; P:one-carbon metabolic process; TAS:GeneDB_Pfalciparum |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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