| Tag |
Content |
LipidDB ID |
LipidDB-33727-00217 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.88 |
Molecular Weight |
74376.19 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
GP2 |
Protein Synonyms/Alias |
GP1,2; GP; Virion spike glycoprotein; |
Gene Name |
GP |
Gene Synonyms/Alias |
|
Created Date |
01-FEB-1994 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
671 | Canonical | AVLIALSCICRIFTK | [1] | S-Palmitoylation | 673 | Canonical | LIALSCICRIFTKYI | [1] | S-Palmitoylation |
|
Organism |
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg viru (strain Kenya/Musoke/1980)) |
NCBI Taxa ID |
33727 |
Reference |
[1] Funke C, Becker S, Dartsch H, Klenk HD, Mühlberger E. Acylation of the Marburgvirus glycoprotein. Virology. 1995 Apr 1;208(1):289-97.[ PMID:11831710]
|
Functional Description |
GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection) (By similarity). |
Sequence Annotation |
Topological domain: 19 648 Extracellular.
Transmembrane: 649 669 Helical.
Topological domain: 670 681 Cytoplasmic.
Region: 38 188 Receptor-binding.
Region: 277 455 Mucin-like region.
Region: 529 549 Fusion peptide.
Functional site: 435 436 Cleavage; by host furin.
|
Protein Length |
681 AA. |
Protein Sequence
(Canonical) |
MKTTCFLISL ILIQGTKNLP ILEIASNNQP QNVDSVCSGT LQKTEDVHLM GFTLSGQKVA 60
DSPLEASKRW AFRTGVPPKN VEYTEGEEAK TCYNISVTDP SGKSLLLDPP TNIRDYPKCK 120
TIHHIQGQNP HAQGIALHLW GAFFLYDRIA STTMYRGKVF TEGNIAAMIV NKTVHKMIFS 180
RQGQGYRHMN LTSTNKYWTS SNGTQTNDTG CFGALQEYNS TKNQTCAPSK IPPPLPTARP 240
EIKLTSTPTD ATKLNTTDPS SDDEDLATSG SGSGEREPHT TSDAVTKQGL SSTMPPTPSP 300
QPSTPQQGGN NTNHSQDAVT ELDKNNTTAQ PSMPPHNTTT ISTNNTSKHN FSTLSAPLQN 360
TTNDNTQSTI TENEQTSAPS ITTLPPTGNP TTAKSTSSKK GPATTAPNTT NEHFTSPPPT 420
PSSTAQHLVY FRRKRSILWR EGDMFPFLDG LINAPIDFDP VPNTKTIFDE SSSSGASAEE 480
DQHASPNISL TLSYFPNINE NTAYSGENEN DCDAELRIWS VQEDDLAAGL SWIPFFGPGI 540
EGLYTAVLIK NQNNLVCRLR RLANQTAKSL ELLLRVTTEE RTFSLINRHA IDFLLTRWGG 600
TCKVLGPDCC IGIEDLSKNI SEQIDQIKKD EQKEGTGWGL GGKWWTSDWG VLTNLGILLL 660
LSIAVLIALS CICRIFTKYI G 681
|
FASTA
(Canonical) |
>LipidDB-33727-00217|P35253
MKTTCFLISLILIQGTKNLPILEIASNNQPQNVDSVCSGTLQKTEDVHLMGFTLSGQKVA
DSPLEASKRWAFRTGVPPKNVEYTEGEEAKTCYNISVTDPSGKSLLLDPPTNIRDYPKCK
TIHHIQGQNPHAQGIALHLWGAFFLYDRIASTTMYRGKVFTEGNIAAMIVNKTVHKMIFS
RQGQGYRHMNLTSTNKYWTSSNGTQTNDTGCFGALQEYNSTKNQTCAPSKIPPPLPTARP
EIKLTSTPTDATKLNTTDPSSDDEDLATSGSGSGEREPHTTSDAVTKQGLSSTMPPTPSP
QPSTPQQGGNNTNHSQDAVTELDKNNTTAQPSMPPHNTTTISTNNTSKHNFSTLSAPLQN
TTNDNTQSTITENEQTSAPSITTLPPTGNPTTAKSTSSKKGPATTAPNTTNEHFTSPPPT
PSSTAQHLVYFRRKRSILWREGDMFPFLDGLINAPIDFDPVPNTKTIFDESSSSGASAEE
DQHASPNISLTLSYFPNINENTAYSGENENDCDAELRIWSVQEDDLAAGLSWIPFFGPGI
EGLYTAVLIKNQNNLVCRLRRLANQTAKSLELLLRVTTEERTFSLINRHAIDFLLTRWGG
TCKVLGPDCCIGIEDLSKNISEQIDQIKKDEQKEGTGWGLGGKWWTSDWGVLTNLGILLL
LSIAVLIALSCICRIFTKYIG
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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