Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-31762-00766
Entry Name
UniProt Accession
Theoretical PI
9.87
Molecular Weight
24060.06
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Large delta antigen
Protein Synonyms/Alias
L-HDAg; p27;
Gene Name
Gene Synonyms/Alias
Created Date
01-APR-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
211
Canonical
PPSSPQSCRPQ****
[1][2]
S-Farnesylation
Organism
Hepatitis delta virus genotype I (isolate D380) (HDV)
NCBI Taxa ID
31762
Reference
[1] Hwang SB, Lai MM. Isoprenylation mediates direct protein-protein interactions between hepatitis large delta antigen and hepatitis B virus surface antigen. JVirol. 1993 Dec;67(12):7659-62.[PMID:8230486]
[2] Otto JC, Casey PJ. The hepatitis delta virus large antigen is farnesylatedboth in vitro and in animal cells. J Biol Chem. 1996 Mar 1;271(9):4569-72. PubMedPMID: 8617711.[PMID:8617711]
Functional Description
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication.
Sequence Annotation
Region: 12 60 Dimerization.
Region: 97 107 RNA-binding.
Region: 136 146 RNA-binding.
Motif: 66 75 Nuclear localization signal.
Modified residue: 2 2 Phosphoserine; by host.
Modified residue: 13 13 Omega-N-methylated arginine; by host.
Modified residue: 72 72 N6-acetyllysine; by host.
Modified residue: 123 123 Phosphoserine; by host.
Modified residue: 177 177 Phosphoserine; by host.
Modified residue: 211 211 Cysteine methyl ester; by host.
Protein Length
214 AA.
Protein Sequence
(Canonical)
MSRPEGRKNR GGREEVLEQW VSGRKKLEEL ERDLRKVKKK IKKLEDEHPW LGNIKGILGK  60
KDKDGEGAPP AKRARTDQME VDSGPRKRPS RGGFTDKERQ DHRRRKALEN KRKQLSAGGK  120
NLSKEEEEEL RRLTEEDERR ERRIAGPQVG GVNPLEGGTR GAPGGGFVPS MQGVPESPFT  180
RTGEGLDIRG SQGFPWDILF PADPPSSPQS CRPQ                              214
FASTA
(Canonical)
>LipidDB-31762-00766|P29996
MSRPEGRKNRGGREEVLEQWVSGRKKLEELERDLRKVKKKIKKLEDEHPWLGNIKGILGK
KDKDGEGAPPAKRARTDQMEVDSGPRKRPSRGGFTDKERQDHRRRKALENKRKQLSAGGK
NLSKEEEEELRRLTEEDERRERRIAGPQVGGVNPLEGGTRGAPGGGFVPSMQGVPESPFT
RTGEGLDIRGSQGFPWDILFPADPPSSPQSCRPQ
Gene Ontology
GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW
GO:0005622; C:intracellular; IEA:GOC
GO:0019012; C:virion; IEA:UniProtKB-KW
GO:0003723; F:RNA binding; IEA:UniProtKB-KW
GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW
GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW
Interpro
InterPro; IPR027403; Delta_antigen_N
InterPro; IPR002506; HDV_ag
Pfam
Pfam; PF01517; HDV_ag;
SMART
PROSITE
PRINTS