LipidDB ID

LipidDB-299386-00278

Entry Name

UniProt Accession

Q91DM1;

Theoretical PI

10.64

Molecular Weight

7370.96

Genbank Protein ID

ABI64072.1; CAC42776.1; ABR92765.1; ABR92772.1; ABR92779.1; ABR92786.1; ABR92807.1; ABR92814.1; ABR92821.1; ABR92828.1; ABR92898.1; ABR92905.1; ABR92912.1; ACE82258.1; ACE82267.1; ACE82276.1;

Genbank Nucleotide ID

DQ846750; X53459; EF492543; EF492544; EF492545; EF492546; EF492549; EF492550; EF492551; EF492552; EF492562; EF492563; EF492564; EU586273; EU586274; EU586275;

Protein Name

Envelope small membrane protein

Protein Synonyms/Alias

Protein E; Glycoprotein 2a; Protein GP2a;

Gene Name

GP2a

Gene Synonyms/Alias

2a;

Created Date

14-OCT-2008

Organism

Equine arteritis virus (strain Bucyrus) (EAV)

NCBI Taxa ID

299386

Reference

[1] Thaa B, Kabatek A, Zevenhoven-Dobbe JC, Snijder EJ, Herrmann A, Veit M.Myristoylation of the arterivirus E protein: the fatty acid modification is notessential for membrane association but contributes significantly to virusinfectivity. J Gen Virol. 2009 Nov;90(Pt 11):2704-12. doi:10.1099/vir.0.011957-0. Epub 2009 Aug 5.[PMID:19656967]

Functional Description

Minor envelope protein. May function as a viroporin in the virion envelope that facilitates uncoating of the virus in order to release the genomic RNA into the cytoplasm for subsequent replication (By similarity).

Sequence Annotation

Topological domain: 2 27 Virion surface.
Transmembrane: 28 48 Helical.
Topological domain: 49 67 Intravirion.
Region: 2 15 Endoplasmic reticulum retention signal.

Protein Length

67 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-KW
GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-KW
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW
GO:0019031; C:viral envelope; IEA:UniProtKB-KW
GO:0005216; F:ion channel activity; IEA:UniProtKB-KW
GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW
GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW

Interpro

Pfam

SMART

PROSITE

PRINTS