LipidDB ID

LipidDB-284812-00666

Entry Name

UniProt Accession

P11620;

Theoretical PI

5.31

Molecular Weight

22816.66

Genbank Protein ID

CAA36319.1; CAA33192.1; CAB66454.1;

Genbank Nucleotide ID

X52099; X15082; CU329671;

Protein Name

GTP-binding protein ypt1

Protein Synonyms/Alias

Gene Name

ypt1

Gene Synonyms/Alias

SPBC1703.10;

Created Date

01-OCT-1989

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

NCBI Taxa ID

284812

Reference

[1] Newman CM, Giannakouros T, Hancock JF, Fawell EH, Armstrong J, Magee AI.Post-translational processing of Schizosaccharomyces pombe YPT proteins. J BiolChem. 1992 Jun 5;267(16):11329-36.[PMID:1597466]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Ypt1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.

Sequence Annotation

Nucleotide-binding: 15 22 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 121 124 GTP.
Motif: 37 45 Effector region.
Modified residue: 164 164 Phosphothreonine.

Protein Length

203 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; IDA:PomBase
GO:0005789; C:endoplasmic reticulum membrane; ISO:PomBase
GO:0000139; C:Golgi membrane; ISO:PomBase
GO:0005634; C:nucleus; IDA:PomBase
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IGI:PomBase
GO:0006995; P:cellular response to nitrogen starvation; IMP:PomBase
GO:0006888; P:ER to Golgi vesicle-mediated transport; ISO:PomBase
GO:0006184; P:GTP catabolic process; IGI:GOC
GO:0006886; P:intracellular protein transport; IC:PomBase
GO:0070317; P:negative regulation of G0 to G1 transition; IMP:PomBase
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;