Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-261995-00306
Entry Name
UniProt Accession
Theoretical PI
9.88
Molecular Weight
24386.48
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Large delta antigen
Protein Synonyms/Alias
L-HDAg; p27;
Gene Name
Gene Synonyms/Alias
Created Date
14-APR-2009
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
211
Canonical
GYYWVPGCTQQ****
[1]
S-Farnesylation
Organism
Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)
NCBI Taxa ID
261995
Reference
[1] O'Malley B, Lazinski DW. Roles of carboxyl-terminal and farnesylated residues in the functions of the large hepatitis delta antigen. J Virol. 2005Jan;79(2):1142-53.[PMID:15613342]
Functional Description
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity).
Sequence Annotation
Region: 12 59 Dimerization.
Region: 96 106 RNA-binding.
Region: 135 145 RNA-binding.
Motif: 65 74 Nuclear localization signal.
Modified residue: 2 2 Phosphoserine; by host.
Modified residue: 13 13 Omega-N-methylated arginine; by host.
Modified residue: 71 71 N6-acetyllysine; by host.
Modified residue: 122 122 Phosphoserine; by host.
Modified residue: 176 176 Phosphoserine; by host.
Modified residue: 211 211 Cysteine methyl ester; by host.
Protein Length
214 AA.
Protein Sequence
(Canonical)
MSQPDARPGS KAREEALEQW VEERKKKRIA EKELRRINKK IKKLEDENPW LGNIVGMLRK  60
KKDEEGGPPA KRPRREDMEI DSTPGRKSKA RGFTDQERRD HRRRKALENK KKQLAGGGKN  120
LSREEEEELR RLARDDDERE RRVAGPRPGG VNPMDGPPRG APGGGFVPSL QGVPESPFSR  180
TGEGIDIRGT QQFPWYGFTP PPPGYYWVPG CTQQ                              214
FASTA
(Canonical)
>LipidDB-261995-00306|P0C6M7
MSQPDARPGSKAREEALEQWVEERKKKRIAEKELRRINKKIKKLEDENPWLGNIVGMLRK
KKDEEGGPPAKRPRREDMEIDSTPGRKSKARGFTDQERRDHRRRKALENKKKQLAGGGKN
LSREEEEELRRLARDDDERERRVAGPRPGGVNPMDGPPRGAPGGGFVPSLQGVPESPFSR
TGEGIDIRGTQQFPWYGFTPPPPGYYWVPGCTQQ
Gene Ontology
GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW
GO:0005622; C:intracellular; IEA:GOC
GO:0019012; C:virion; IEA:UniProtKB-KW
GO:0003723; F:RNA binding; IEA:UniProtKB-KW
GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW
GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW
Interpro
InterPro; IPR027403; Delta_antigen_N
InterPro; IPR002506; HDV_ag
Pfam
Pfam; PF01517; HDV_ag;
SMART
PROSITE
PRINTS