LipidDB-237561-01226

Lipid Modification Database

Tag

Content

LipidDB ID

Entry Name

ARF_CANAL

UniProt Accession

P22274; Q5A316;

Theoretical PI

5.11

Molecular Weight

20233.32

Genbank Protein ID

AAA64266.1; AAB23053.2; EAK97201.1; EAK97288.1;

Genbank Nucleotide ID

M54910; S43354; AACQ01000073; AACQ01000072;

Protein Name

ADP-ribosylation factor

Protein Synonyms/Alias

Gene Name

ARF1

Gene Synonyms/Alias

CaO19.13805; CaO19.6447;

Created Date

01-AUG-1991

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
2	Canonical	******MGLTISKLF	[1]	N-Myristoylation

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

NCBI Taxa ID

237561

Reference

[1] Lodge JK, Jackson-Machelski E, Devadas B, Zupec ME, Getman DP, Kishore N,Freeman SK, McWherter CA, Sikorski JA, Gordon JI. N-myristoylation of Arfproteins in Candida albicans: an in vivo assay for evaluating antifungalinhibitors of myristoyl-CoA: protein N-myristoyltransferase. Microbiology. 1997Feb;143 ( Pt 2):357-66.[PMID:9043113]

Functional Description

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Sequence Annotation

Nucleotide-binding: 24 31 GTP.
Nucleotide-binding: 67 71 GTP.
Nucleotide-binding: 126 129 GTP.

Protein Length

179 AA.

Protein Sequence
(Canonical)

MGLTISKLFA SLLGRREMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN  60
ISFTVWDVGG QDKIRPLWRY YFQNTQGIIF VVDSNDRDRI NEAREELQSM LNEDELKDAV  120
LLVLANKQDL PNAMNAAEIT EKMGLHSIMN RPWFIQATCA TTGDGLYEGL EWLSNQVGK   179

FASTA
(Canonical)

>LipidDB-237561-01226|P22274
MGLTISKLFASLLGRREMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ISFTVWDVGGQDKIRPLWRYYFQNTQGIIFVVDSNDRDRINEAREELQSMLNEDELKDAV
LLVLANKQDLPNAMNAAEITEKMGLHSIMNRPWFIQATCATTGDGLYEGLEWLSNQVGK

Gene Ontology

GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0035690; P:cellular response to drug; IMP:CGD
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR024156; Small_GTPase_ARF
InterPro; IPR006689; Small_GTPase_ARF/SAR

Pfam

Pfam; PF00025; Arf;

SMART

SMART; SM00177; ARF;

PROSITE

PROSITE; PS51417; ARF;

PRINTS

PRINTS; PR00328; SAR1GTPBP;