LipidDB-227859-00391

Lipid Modification Database

Tag

Content

LipidDB ID

Entry Name

VEMP_CVHSA

UniProt Accession

P59637; Q7TA13; Q7TFA8;

Theoretical PI

6.01

Molecular Weight

8361.0

Genbank Protein ID

AAP13443.1; AAP41040.1; AAP13570.1; AAP30033.1; AAP51230.1; AAP37020.1; AAP50488.1; AAP33700.1; AAP73416.1; AAP82979.2; AAQ01600.1; AAQ01612.1; AAP97885.1; BAC81351.1; BAC81365.1; BAC81379.1; BAC81393.1; BAC81407.1; AAP72977.1; AAQ94063.1;

Genbank Nucleotide ID

AY278741; AY274119; AY304492; AY282752; AY278554; AY278491; AY283794; AY283795; AY283796; AY283797; AY283798; AY278487; AY278488; AY278489; AY278490; AY279354; AY291451; AY310120; AY291315; AY297028; AY323975; AY321118; AY463059; AY338174; AY338175; AY348314; AP006557; AP006558; AP006559; AP006560; AP006561; AY323977; AY362698; AY362699; AY427439;

Protein Name

Envelope small membrane protein

Protein Synonyms/Alias

E protein; sM protein;

Gene Name

Gene Synonyms/Alias

sM; 4;

Created Date

23-APR-2003

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
40	Canonical	ILTALRLCAYCCNIV	[1]	S-Palmitoylation
43	Canonical	ALRLCAYCCNIVNVS	[1]	S-Palmitoylation
44	Canonical	LRLCAYCCNIVNVSL	[1]	S-Palmitoylation

Organism

Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrom coronavirus)

NCBI Taxa ID

227859

Reference

[1] Liao Y, Yuan Q, Torres J, Tam JP, Liu DX. Biochemical and functionalcharacterization of the membrane association and membrane permeabilizing activityof the severe acute respiratory syndrome coronavirus envelope protein. Virology. 2006 Jun 5;349(2):264-75. Epub 2006 Feb 28.[PMID:16507314]

Functional Description

Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis (By similarity).

Sequence Annotation

Topological domain: 1 16 Virion surface.
Transmembrane: 17 37 Helical.
Topological domain: 38 76 Intravirion.

Protein Length

76 AA.

Protein Sequence
(Canonical)

MYSFVSEETG TLIVNSVLLF LAFVVFLLVT LAILTALRLC AYCCNIVNVS LVKPTVYVYS 60
RVKNLNSSEG VPDLLV 76

FASTA
(Canonical)

>LipidDB-227859-00391|P59637
MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYS
RVKNLNSSEGVPDLLV

Gene Ontology

GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-KW
GO:0033644; C:host cell membrane; IEA:UniProtKB-KW
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0019031; C:viral envelope; IEA:UniProtKB-KW
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW

Interpro

InterPro; IPR003873; NS3_envE

Pfam

Pfam; PF02723; NS3_envE;

SMART

PROSITE

PRINTS