| Tag |
Content |
LipidDB ID |
LipidDB-11926-01020 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.46 |
Molecular Weight |
47496.4 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Nucleocapsid protein p15-gag |
Protein Synonyms/Alias |
Pr53Gag; MA; CA; NC-gag; |
Gene Name |
gag |
Gene Synonyms/Alias |
|
Created Date |
21-JUL-1986 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGQIFSRSA | [1] | N-Myristoylation |
|
Organism |
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) |
NCBI Taxa ID |
11926 |
Reference |
[1] Hayakawa T, Miyazaki T, Misumi Y, Kobayashi M, Fujisawa Y.Myristoylation-dependent membrane targeting and release of the HTLV-I Gagprecursor, Pr53gag, in yeast. Gene. 1992 Oct 1;119(2):273-7.[ PMID:1398108]
|
Functional Description |
Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). |
Sequence Annotation |
Motif: 118 121 PPXY motif.
Motif: 124 127 PTAP/PSAP motif.
Functional site: 130 131 Cleavage; by viral protease.
Functional site: 344 345 Cleavage; by viral protease.
Modified residue: 105 105 Phosphoserine; by host MAPK1.
|
Protein Length |
429 AA. |
Protein Sequence
(Canonical) |
MGQIFSRSAS PIPRPPRGLA AHHWLNFLQA AYRLEPGPSS YDFHQLKKFL KIALETPARI 60
CPINYSLLAS LLPKGYPGRV NEILHILIQT QAQIPSRPAP PPPSSPTHDP PDSDPQIPPP 120
YVEPTAPQVL PVMHPHGAPP NHRPWQMKDL QAIKQEVSQA APGSPQFMQT IRLAVQQFDP 180
TAKDLQDLLQ YLCSSLVASL HHQQLDSLIS EAETRGITGY NPLAGPLRVQ ANNPQQQGLR 240
REYQQLWLAA FAALPGSAKD PSWASILQGL EEPYHAFVER LNIALDNGLP EGTPKDPILR 300
SLAYSNANKE CQKLLQARGH TNSPLGDMLR ACQTWTPKDK TKVLVVQPKK PPPNQPCFRC 360
GKAGHWSRDC TQPRPPPGPC PLCQDPTHWK RDCPRLKPTI PEPEPEEDAL LLDLPADIPH 420
PKNSIGGEV 429
|
FASTA
(Canonical) |
>LipidDB-11926-01020|P03345
MGQIFSRSASPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKKFLKIALETPARI
CPINYSLLASLLPKGYPGRVNEILHILIQTQAQIPSRPAPPPPSSPTHDPPDSDPQIPPP
YVEPTAPQVLPVMHPHGAPPNHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDP
TAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLR
REYQQLWLAAFAALPGSAKDPSWASILQGLEEPYHAFVERLNIALDNGLPEGTPKDPILR
SLAYSNANKECQKLLQARGHTNSPLGDMLRACQTWTPKDKTKVLVVQPKKPPPNQPCFRC
GKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPTIPEPEPEEDALLLDLPADIPH
PKNSIGGEV
|
Gene Ontology |
|
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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