| Tag |
Content |
LipidDB ID |
LipidDB-11888-00737 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.68 |
Molecular Weight |
65660.64 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Transmembrane protein |
Protein Synonyms/Alias |
Env polyprotein; SU; Glycoprotein 85; gp85; TM; Glycoprotein 37; gp37; |
Gene Name |
env |
Gene Synonyms/Alias |
|
Created Date |
21-JUL-1986 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
569 | Canonical | VILLLLVCLPCLLQF | [1] | S-Palmitoylation | 572 | Canonical | LLLVCLPCLLQFVSS | [1] | S-Palmitoylation |
|
Organism |
Rous sarcoma virus (strain Prague C) (RSV-PrC) |
NCBI Taxa ID |
11888 |
Reference |
[1] Ochsenbauer-Jambor C, Miller DC, Roberts CR, Rhee SS, Hunter E. Palmitoylationof the Rous sarcoma virus transmembrane glycoprotein is required for proteinstability and virus infectivity. J Virol. 2001 Dec;75(23):11544-54.[ PMID:11689636]
|
Functional Description |
The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane (By similarity). |
Sequence Annotation |
Topological domain: 65 556 Extracellular.
Transmembrane: 557 577 Helical.
Topological domain: 578 603 Cytoplasmic.
Region: 422 442 Fusion peptide.
Region: 478 494 Immunosuppression.
Functional site: 405 406 Cleavage; by host.
|
Protein Length |
603 AA. |
Protein Sequence
(Canonical) |
MRRALFLQAF LTGYPGKTSK KDSKEKPLAT SKKDPEKTPL LPTRVNYILI IGVLVLCEVT 60
GVRADVHLLE QPGNLWITWA NRTGQTDFCL STQSATSPFQ TCLIGIPSPI SEGDFKGYVS 120
DTNCSTVGTD RLVLSASITG GPDNSTTLTY RKVSCLLLKL NVSMWDEPPE LQLLGSQSLP 180
NVTNITQVSG VAGGCVYFAP RATGLFLGWS KQGLSRFLLR HPFTSTSNST EPFTVVTADR 240
HNLFMGSEYC GAYGYRFWEI YNCSQTRNTY RCGDVGGTGL PETWCRGKGG IWVNQSKEIN 300
ETEPFSFTAN CTGSNLGNVS GCCGEPITIL PLGAWIDSTQ GSFTKPKALP PAIFLICGDR 360
AWQGIPSRPV GGPCYLGKLT MLAPNHTDIL KILANSSRTG IRRKRSVSHL DDTCSDEVQL 420
WGPTARIFAS ILAPGVAAAQ ALREIERLAC WSVKQANLTT SLLGDLLDDV TSIRHAVLQN 480
RAAIDFLLLA HGHGCEDVAG MCCFNLSDHS ESIQKKFQLM KKHVNKIGVD SDPIGSWLRG 540
IFGGIGEWAV HLLKGLLLGL VVILLLLVCL PCLLQFVSSS IRKMINSSIN YHTEYRKMQG 600
GAV 603
|
FASTA
(Canonical) |
>LipidDB-11888-00737|P03396
MRRALFLQAFLTGYPGKTSKKDSKEKPLATSKKDPEKTPLLPTRVNYILIIGVLVLCEVT
GVRADVHLLEQPGNLWITWANRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVS
DTNCSTVGTDRLVLSASITGGPDNSTTLTYRKVSCLLLKLNVSMWDEPPELQLLGSQSLP
NVTNITQVSGVAGGCVYFAPRATGLFLGWSKQGLSRFLLRHPFTSTSNSTEPFTVVTADR
HNLFMGSEYCGAYGYRFWEIYNCSQTRNTYRCGDVGGTGLPETWCRGKGGIWVNQSKEIN
ETEPFSFTANCTGSNLGNVSGCCGEPITILPLGAWIDSTQGSFTKPKALPPAIFLICGDR
AWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQL
WGPTARIFASILAPGVAAAQALREIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQN
RAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKKHVNKIGVDSDPIGSWLRG
IFGGIGEWAVHLLKGLLLGLVVILLLLVCLPCLLQFVSSSIRKMINSSINYHTEYRKMQG
GAV
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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