| Tag |
Content |
LipidDB ID |
LipidDB-11774-01089 |
Entry Name |
|
UniProt Accession |
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Theoretical PI |
8.3 |
Molecular Weight |
47008.59 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Capsid protein p30 |
Protein Synonyms/Alias |
Core polyprotein; MA; pp12; CA; |
Gene Name |
gag |
Gene Synonyms/Alias |
|
Created Date |
21-JUL-1986 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
79 | Canonical | LIAETVMGQTITTPL | [1] | N-Myristoylation |
|
Organism |
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV (Gardner-Arnstein feline leukemia oncovirus B) |
NCBI Taxa ID |
11774 |
Reference |
[1] Maurer-Stroh S, Eisenhaber B, Eisenhaber F. N-terminal N-myristoylation ofproteins: prediction of substrate proteins from amino acid sequence. J Mol Biol. 2002 Apr 5;317(4):541-57.[ PMID:11955008]
|
Functional Description |
Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release (By similarity). |
Sequence Annotation |
Motif: 195 198 PTAP/PSAP motif.
Motif: 234 237 PPXY motif.
Functional site: 204 205 Cleavage; by viral protease.
Functional site: 274 275 Cleavage; by viral protease.
|
Protein Length |
425 AA. |
Protein Sequence
(Canonical) |
MSRASSGTAT GARLFGISSV LGEYRVLIGD EGAGPSRSPS EVSFSVWYRS RAARLVIVCL 60
VASFLVPCLT FLIAETVMGQ TITTPLSLTL DHWSEVRARA HNQGVEVRKK KWITLCEAEW 120
VMMNVGWPRE GTFSLDNISQ VEKKIFAPGP YGHPDQVPYI TTWRSLATDP PSWVRPFLPP 180
PKPPTSLPQP LSPQPSAPLT SSLYPVLPKS DPPKPPVLPP DPSSPLIDLL TEEPPPYPGG 240
HGPPPSGPRT PTASPIASRL RERRENPAEE SQALPLREGP NNRPQYWPFS ASDLYNWKSH 300
NPPFSQDPVA LTNLIESILV THQPTWDDCQ QLLQALLTGE ERQRVLLEAR KQVPGEDGRP 360
TQLPNVIDET FPLTRPNWDF ATPAGREHLR LYRQLLLAGL RGAARRPTNL AQVKQVVQGK 420
EETPA 425
|
FASTA
(Canonical) |
>LipidDB-11774-01089|P03337
MSRASSGTATGARLFGISSVLGEYRVLIGDEGAGPSRSPSEVSFSVWYRSRAARLVIVCL
VASFLVPCLTFLIAETVMGQTITTPLSLTLDHWSEVRARAHNQGVEVRKKKWITLCEAEW
VMMNVGWPREGTFSLDNISQVEKKIFAPGPYGHPDQVPYITTWRSLATDPPSWVRPFLPP
PKPPTSLPQPLSPQPSAPLTSSLYPVLPKSDPPKPPVLPPDPSSPLIDLLTEEPPPYPGG
HGPPPSGPRTPTASPIASRLRERRENPAEESQALPLREGPNNRPQYWPFSASDLYNWKSH
NPPFSQDPVALTNLIESILVTHQPTWDDCQQLLQALLTGEERQRVLLEARKQVPGEDGRP
TQLPNVIDETFPLTRPNWDFATPAGREHLRLYRQLLLAGLRGAARRPTNLAQVKQVVQGK
EETPA
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016020; C:membrane; IEA:UniProtKB-KW GO:0019028; C:viral capsid; IEA:UniProtKB-KW GO:0003723; F:RNA binding; IEA:UniProtKB-KW GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW GO:0019076; P:viral release from host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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