| Tag |
Content |
LipidDB ID |
LipidDB-11734-01058 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.72 |
Molecular Weight |
101251.81 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Transmembrane protein gp41 |
Protein Synonyms/Alias |
Env polyprotein; SU; Glycoprotein 120; gp120; TM; Glycoprotein 32; gp32; |
Gene Name |
env |
Gene Synonyms/Alias |
|
Created Date |
01-NOV-1988 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
789 | Canonical | LTWLFSNCRTLLSRA | [1] | S-Palmitoylation |
|
Organism |
Simian immunodeficiency virus (isolate Mm251) (SIV-mac) (Simia immunodeficiency virus rhesus monkey) |
NCBI Taxa ID |
11734 |
Reference |
[1] Vzorov AN, Weidmann A, Kozyr NL, Khaoustov V, Yoffe B, Compans RW. Role of thelong cytoplasmic domain of the SIV Env glycoprotein in early and late stages ofinfection. Retrovirology. 2007 Dec 14;4:94.[ PMID:18081926]
|
Functional Description |
The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). |
Sequence Annotation |
Topological domain: 20 696 Extracellular.
Transmembrane: 697 717 Helical.
Topological domain: 718 881 Cytoplasmic.
Region: 113 169 V1.
Region: 170 213 V2.
Region: 313 345 V3.
Region: 404 434 V4.
Region: 477 484 V5.
Region: 528 548 Fusion peptide.
Region: 591 607 Immunosuppression.
Region: 673 694 MPER; binding to GalCer.
Motif: 723 726 YXXV motif; contains endocytosis signal.
Motif: 880 881 Di-leucine internalization motif.
Functional site: 527 528 Cleavage; by host furin.
Functional site: 736 736 In-frame UAG termination codon.
|
Protein Length |
881 AA. |
Protein Sequence
(Canonical) |
MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD 60
NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDR 120
WGLTKSSTTI TTAAPTSAPV SEKIDMVNET SSCIAQNNCT GLEQEQMISC KFTMTGLKRD 180
KTKEYNETWY STDLVCEQGN STDNESRCYM NHCNTSVIQE SCDKHYWDTI RFRYCAPPGY 240
ALLRCNDTNY SGFMPKCSKV VVSSCTRMME TQTSTWFGFN GTRAENRTYI YWHGRDNRTI 300
ISLNKYYNLT MKCRRPGNKT VLPVTIMSGL VFHSQPINDR PKQAWCWFGG KWKDAIKEVK 360
QTIVKHPRYT GTNNTDKINL TAPGGGDPEV TFMWTNCRGE FLYCKMNWFL NWVEDRDVTT 420
QRPKERHRRN YVPCHIRQII NTWHKVGKNV YLPPREGDLT CNSTVTSLIA NIDWTDGNQT 480
SITMSAEVAE LYRLELGDYK LVEITPIGLA PTDVKRYTTG GTSRNKRGVF VLGFLGFLAT 540
AGSAMGAASL TLTAQSRTLL AGIVQQQQQL LDVVKRQQEL LRLTVWGTKN LQTRVTAIEK 600
YLKDQAQLNA WGCAFRQVCH TTVPWPNASL TPDWNNDTWQ EWERKVDFLE ENITALLEEA 660
QIQQEKNMYE LQKLNSWDVF GNWFDLASWI KYIQYGIYVV VGVILLRIVI YIVQMLAKLR 720
QGYRPVFSSP PSYFQXTHTQ QDPALPTREG KEGDGGEGGG NSSWPWQIEY IHFLIRQLIR 780
LLTWLFSNCR TLLSRAYQIL QPILQRLSAT LRRVREVLRT ELTYLQYGWS YFHEAVQAGW 840
RSATETLAGA WRDLWETLRR GGRWILAIPR RIRQGLELTL L 881
|
FASTA
(Canonical) |
>LipidDB-11734-01058|P08810
MGCLGNQLLIAILLLSVYGIYCTQYVTVFYGVPAWRNATIPLFCATKNRDTWGTTQCLPD
NGDYSELALNVTESFDAWENTVTEQAIEDVWQLFETSIKPCVKLSPLCITMRCNKSETDR
WGLTKSSTTITTAAPTSAPVSEKIDMVNETSSCIAQNNCTGLEQEQMISCKFTMTGLKRD
KTKEYNETWYSTDLVCEQGNSTDNESRCYMNHCNTSVIQESCDKHYWDTIRFRYCAPPGY
ALLRCNDTNYSGFMPKCSKVVVSSCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTI
ISLNKYYNLTMKCRRPGNKTVLPVTIMSGLVFHSQPINDRPKQAWCWFGGKWKDAIKEVK
QTIVKHPRYTGTNNTDKINLTAPGGGDPEVTFMWTNCRGEFLYCKMNWFLNWVEDRDVTT
QRPKERHRRNYVPCHIRQIINTWHKVGKNVYLPPREGDLTCNSTVTSLIANIDWTDGNQT
SITMSAEVAELYRLELGDYKLVEITPIGLAPTDVKRYTTGGTSRNKRGVFVLGFLGFLAT
AGSAMGAASLTLTAQSRTLLAGIVQQQQQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEK
YLKDQAQLNAWGCAFRQVCHTTVPWPNASLTPDWNNDTWQEWERKVDFLEENITALLEEA
QIQQEKNMYELQKLNSWDVFGNWFDLASWIKYIQYGIYVVVGVILLRIVIYIVQMLAKLR
QGYRPVFSSPPSYFQXTHTQQDPALPTREGKEGDGGEGGGNSSWPWQIEYIHFLIRQLIR
LLTWLFSNCRTLLSRAYQILQPILQRLSATLRRVREVLRTELTYLQYGWSYFHEAVQAGW
RSATETLAGAWRDLWETLRRGGRWILAIPRRIRQGLELTLL
|
Gene Ontology |
GO:0044174; C:host cell endosome; IEA:UniProtKB-KW GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0005198; F:structural molecule activity; IEA:InterPro GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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