| Tag |
Content |
LipidDB ID |
LipidDB-11696-00267 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.3 |
Molecular Weight |
56760.9 |
Genbank Protein ID |
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Genbank Nucleotide ID |
|
Protein Name |
p6-gag |
Protein Synonyms/Alias |
Pr55Gag; MA; CA; NC; |
Gene Name |
gag |
Gene Synonyms/Alias |
|
Created Date |
01-NOV-1988 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGARASVLS | [1] | N-Myristoylation |
|
Organism |
Human immunodeficiency virus type 1 group M subtype B (isolate MN (HIV-1) |
NCBI Taxa ID |
11696 |
Reference |
[1] Henderson LE, Bowers MA, Sowder RC 2nd, Serabyn SA, Johnson DG, Bess JW Jr,Arthur LO, Bryant DK, Fenselau C. Gag proteins of the highly replicative MNstrain of human immunodeficiency virus type 1: posttranslational modifications,proteolytic processings, and complete amino acid sequences. J Virol. 1992Apr;66(4):1856-65.[ PMID:1548743]
|
Functional Description |
Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu.Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. |
Sequence Annotation |
Motif: 16 22 Nuclear export signal.
Motif: 26 32 Nuclear localization signal.
Motif: 458 461 PTAP/PSAP motif.
Motif: 490 499 LYPX(n)L motif.
Functional site: 135 136 Cleavage; by viral protease.
Functional site: 366 367 Cleavage; by viral protease.
Functional site: 380 381 Cleavage; by viral protease.
Functional site: 435 436 Cleavage; by viral protease.
Functional site: 451 452 Cleavage; by viral protease.
Modified residue: 390 390 Asymmetric dimethylarginine; inNucleocapsid protein p7; by host PRMT6.
Modified residue: 412 412 Asymmetric dimethylarginine; inNucleocapsid protein p7; by host PRMT6.
|
Protein Length |
507 AA. |
Protein Sequence
(Canonical) |
MGARASVLSG GELDRWEKIR LRPGGKKKYK LKHVVWASRE LERFAINPGL LETSEGCRQI 60
LGQLQPSLQT GSEERKSLYN TVATLYCVHQ KIKIKDTKEA LEKIEEEQNK SKKKAQQAAA 120
DTGNRGNSSQ VSQNYPIVQN IQGQMVHQAI SPRTLNAWVK VVEEKAFSPE VIPMFSALSE 180
GATPQDLNTM LNTVGGHQAA MQMLKETINE EAAEWDRLHP AHAGPIAPGQ MREPRGSDIA 240
GTTSTLQEQI GWMTNNPPIP VGEIYKRWII LGLNKIVRMY SPSSILDIRQ GPKEPFRDYV 300
DRFYKTLRAE QASQEVKNWM TETLLVQNAN PDCKTILKAL GPAATLEEMM TACQGVGGPG 360
HKARVLAEAM SQVTNSATIM MQRGNFRNQR KIIKCFNCGK EGHIAKNCRA PRKRGCWKCG 420
KEGHQMKDCT ERQANFLGKI WPSCKGRPGN FPQSRTEPTA PPEESFRFGE ETTTPYQKQE 480
KKQETIDKDL YPLASLKSLF GNDPLSQ 507
|
FASTA
(Canonical) |
>LipidDB-11696-00267|P05888
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHVVWASRELERFAINPGLLETSEGCRQI
LGQLQPSLQTGSEERKSLYNTVATLYCVHQKIKIKDTKEALEKIEEEQNKSKKKAQQAAA
DTGNRGNSSQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSE
GATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPAHAGPIAPGQMREPRGSDIA
GTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPSSILDIRQGPKEPFRDYV
DRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPG
HKARVLAEAMSQVTNSATIMMQRGNFRNQRKIIKCFNCGKEGHIAKNCRAPRKRGCWKCG
KEGHQMKDCTERQANFLGKIWPSCKGRPGNFPQSRTEPTAPPEESFRFGEETTTPYQKQE
KKQETIDKDLYPLASLKSLFGNDPLSQ
|
Gene Ontology |
GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016020; C:membrane; IEA:UniProtKB-KW GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW GO:0003723; F:RNA binding; IEA:UniProtKB-KW GO:0005198; F:structural molecule activity; IEA:InterPro GO:0008270; F:zinc ion binding; IEA:InterPro GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW GO:0019076; P:viral release from host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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