| Tag |
Content |
LipidDB ID |
LipidDB-11674-00714 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.3 |
Molecular Weight |
97941.38 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Transmembrane protein |
Protein Synonyms/Alias |
Env polyprotein; SU; Glycoprotein 100; gp100; TM; Glycoprotein 36; gp36; |
Gene Name |
env |
Gene Synonyms/Alias |
|
Created Date |
01-APR-1990 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
804 | Canonical | GVLLLILCLPTLVDC | [1] | S-Palmitoylation | 811 | Canonical | CLPTLVDCIRNCIHK | [1] | S-Palmitoylation | 815 | Canonical | LVDCIRNCIHKILGY | [1] | S-Palmitoylation | 848 | Canonical | LRRNGRQCGMSEKEE | [1] | S-Palmitoylation |
|
Organism |
Feline immunodeficiency virus (isolate Petaluma) (FIV) |
NCBI Taxa ID |
11674 |
Reference |
[1] González SA, Paladino MG, Affranchino JL. Palmitoylation of the felineimmunodeficiency virus envelope glycoprotein and its effect on fusion activityand envelope incorporation into virions. Virology. 2012 Jun 20;428(1):1-10. doi: 10.1016/j.virol.2012.03.005. Epub 2012 Apr 12.[ PMID:22503389]
|
Functional Description |
The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane (By similarity). |
Sequence Annotation |
Topological domain: 1 785 Extracellular.
Transmembrane: 786 806 Helical.
Topological domain: 807 856 Cytoplasmic.
Region: 616 636 Fusion peptide.
Region: 662 680 Immunosuppression.
Functional site: 611 612 Cleavage; by host.
|
Protein Length |
856 AA. |
Protein Sequence
(Canonical) |
MAEGFAANRQ WIGPEEAEEL LDFDIATQMS EEGPLNPGVN PFRVPGITEK EKQNYCNILQ 60
PKLQDLRNEI QEVKLEEGNA GKFRRARFLR YSDERVLSLV HAFIGYCIYL GNRNKLGSLR 120
HDIDIEAPQE ECYNNREKGT TDNIKYGRRC CLGTVTLYLI LFTGVIVYSQ TAGAQVVWRL 180
PPLVVPVEES EIIFWDCWAP EEPACQDFLG AMIHLKAKTN ISIREGPTLG NWAREIWATL 240
FKKATRQCRR GRIWKRWNET ITGPSGCANN TCYNVSVIVP DYQCYLDRVD TWLQGKINIS 300
LCLTGGKMLY NKVTKQLSYC TDPLQIPLIN YTFGPNQTCM WNTSQIQDPE IPKCGWWNQM 360
AYYNSCKWEE AKVKFHCQRT QSQPGSWFRA ISSWKQRNRW EWRPDFKSKK VKISLPCNST 420
KNLTFAMRSS GDYGEVTGAW IEFGCHRNKS NLHTEARFRI RCRWNVGSDT SLIDTCGNTP 480
NVSGANPVDC TMYSNKMYNC SLQNGFTMKV DDLIVHFNMT KAVEMYNIAG NWSCTSDLPS 540
SWGYMNCNCT NSSSSYSGTK MACPSNRGIL RNWYNPVAGL RQSLEQYQVV KQPDYLLVPE 600
EVMEYKPRRK RAAIHVMLAL ATVLSIAGAG TGATAIGMVT QYHQVLATHQ EAIEKVTGAL 660
KINNLRLVTL EHQVLVIGLK VEAMEKFLYT AFAMQELGCN QNQFFCKIPL ELWTRYNMTI 720
NQTIWNHGNI TLGEWYNQTK DLQQKFYEII MDIEQNNVQG KTGIQQLQKW EDWVRWIGNI 780
PQYLKGLLGG ILGIGLGVLL LILCLPTLVD CIRNCIHKIL GYTVIAMPEV EGEEIQPQME 840
LRRNGRQCGM SEKEEE 856
|
FASTA
(Canonical) |
>LipidDB-11674-00714|P16090
MAEGFAANRQWIGPEEAEELLDFDIATQMSEEGPLNPGVNPFRVPGITEKEKQNYCNILQ
PKLQDLRNEIQEVKLEEGNAGKFRRARFLRYSDERVLSLVHAFIGYCIYLGNRNKLGSLR
HDIDIEAPQEECYNNREKGTTDNIKYGRRCCLGTVTLYLILFTGVIVYSQTAGAQVVWRL
PPLVVPVEESEIIFWDCWAPEEPACQDFLGAMIHLKAKTNISIREGPTLGNWAREIWATL
FKKATRQCRRGRIWKRWNETITGPSGCANNTCYNVSVIVPDYQCYLDRVDTWLQGKINIS
LCLTGGKMLYNKVTKQLSYCTDPLQIPLINYTFGPNQTCMWNTSQIQDPEIPKCGWWNQM
AYYNSCKWEEAKVKFHCQRTQSQPGSWFRAISSWKQRNRWEWRPDFKSKKVKISLPCNST
KNLTFAMRSSGDYGEVTGAWIEFGCHRNKSNLHTEARFRIRCRWNVGSDTSLIDTCGNTP
NVSGANPVDCTMYSNKMYNCSLQNGFTMKVDDLIVHFNMTKAVEMYNIAGNWSCTSDLPS
SWGYMNCNCTNSSSSYSGTKMACPSNRGILRNWYNPVAGLRQSLEQYQVVKQPDYLLVPE
EVMEYKPRRKRAAIHVMLALATVLSIAGAGTGATAIGMVTQYHQVLATHQEAIEKVTGAL
KINNLRLVTLEHQVLVIGLKVEAMEKFLYTAFAMQELGCNQNQFFCKIPLELWTRYNMTI
NQTIWNHGNITLGEWYNQTKDLQQKFYEIIMDIEQNNVQGKTGIQQLQKWEDWVRWIGNI
PQYLKGLLGGILGIGLGVLLLILCLPTLVDCIRNCIHKILGYTVIAMPEVEGEEIQPQME
LRRNGRQCGMSEKEEE
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0005198; F:structural molecule activity; IEA:InterPro GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
InterPro; IPR018582; Envelope_glycop_lentivirus InterPro; IPR000328; Retroviral_envelope_protein |
Pfam |
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SMART |
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PROSITE |
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PRINTS |
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