| Tag |
Content |
LipidDB ID |
LipidDB-11619-00333 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.71 |
Molecular Weight |
55607.35 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Glycoprotein G2 |
Protein Synonyms/Alias |
SSP; GP1; GP2; |
Gene Name |
GPC |
Gene Synonyms/Alias |
GP-C; |
Created Date |
01-MAY-1992 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGQFISFMQ | [1] | N-Myristoylation |
|
Organism |
Junin arenavirus (JUNV) |
NCBI Taxa ID |
11619 |
Reference |
[1] York J, Romanowski V, Lu M, Nunberg JH. The signal peptide of the Junínarenavirus envelope glycoprotein is myristoylated and forms an essential subunit of the mature G1-G2 complex. J Virol. 2004 Oct;78(19):10783-92.[ PMID:15367645]
|
Functional Description |
Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH- dependent glycoprotein-mediated cell fusion (By similarity). |
Sequence Annotation |
Topological domain: 2 17 Extracellular.
Transmembrane: 18 32 Helical.
Topological domain: 33 33 Cytoplasmic.
Transmembrane: 34 53 Helical.
Topological domain: 54 58 Extracellular.
Topological domain: 59 424 Extracellular.
Transmembrane: 425 445 Helical.
Topological domain: 446 485 Cytoplasmic.
Region: 476 477 Involved in ER localization.
Region: 482 483 Involved in ER localization.
Functional site: 58 59 Cleavage; by host signal peptidase.
Functional site: 251 252 Cleavage; by host MBTPS1.
|
Protein Length |
485 AA. |
Protein Sequence
(Canonical) |
MGQFISFMQE IPTFLQEALN IALVAVSLIA IIKGVVNLYK SGLFQFFVFL ALAGRSCTEE 60
AFKIGLHTEF QTVSFSMVGL FSNNPHDLPL LCTLNKSHLY IKGGNASFKI SFDDIAVLLP 120
EYDVIIQHPA DMSWCSKSDD QIWLSQWFMN AVGHDWYLDP PFLCRNRTKT EGFIFQVNTS 180
KTGINENYAK KFKTGMHHLY REYPDSCLDG KLCLMKAQPT SWPLQCPLDH VNTLHFLTRG 240
KNIQLPRRSL KAFFSWSLTD SSGKDTPGGY CLEEWMLVAA KMKCFGNTAV AKCNLNHDSE 300
FCDMLRLFDY NKNAIKTLND ETKKQVNLMG QTINALISDN LLMKNKIREL MSVPYCNYTK 360
FWYVNHTLSG QHSLPRCWLI KNNSYLNISD FRNDWILESD FLISEMLSKE YSDRQGKTPL 420
TLVDICFWST VFFTASLFLH LVGIPTHRHI RGEACPLPHR LNSLGGCRCG KYPNLKKPTV 480
WRRGH 485
|
FASTA
(Canonical) |
>LipidDB-11619-00333|P26313
MGQFISFMQEIPTFLQEALNIALVAVSLIAIIKGVVNLYKSGLFQFFVFLALAGRSCTEE
AFKIGLHTEFQTVSFSMVGLFSNNPHDLPLLCTLNKSHLYIKGGNASFKISFDDIAVLLP
EYDVIIQHPADMSWCSKSDDQIWLSQWFMNAVGHDWYLDPPFLCRNRTKTEGFIFQVNTS
KTGINENYAKKFKTGMHHLYREYPDSCLDGKLCLMKAQPTSWPLQCPLDHVNTLHFLTRG
KNIQLPRRSLKAFFSWSLTDSSGKDTPGGYCLEEWMLVAAKMKCFGNTAVAKCNLNHDSE
FCDMLRLFDYNKNAIKTLNDETKKQVNLMGQTINALISDNLLMKNKIRELMSVPYCNYTK
FWYVNHTLSGQHSLPRCWLIKNNSYLNISDFRNDWILESDFLISEMLSKEYSDRQGKTPL
TLVDICFWSTVFFTASLFLHLVGIPTHRHIRGEACPLPHRLNSLGGCRCGKYPNLKKPTV
WRRGH
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0075512; P:clathrin-mediated endocytosis of virus by host cell; IEA:UniProtKB-KW GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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