| Tag |
Content |
LipidDB ID |
LipidDB-11285-00975 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.15 |
Molecular Weight |
57481.57 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Glycoprotein G |
Protein Synonyms/Alias |
|
Gene Name |
G |
Gene Synonyms/Alias |
|
Created Date |
21-JUL-1986 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
489 | Canonical | LRVGIHLCIKLKHTK | [1] | S-Palmitoylation |
|
Organism |
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) |
NCBI Taxa ID |
11285 |
Reference |
[1] Linder ME, Deschenes RJ. New insights into the mechanisms of proteinpalmitoylation. Biochemistry. 2003 Apr 22;42(15):4311-20. Review.[ PMID:12693927]
|
Functional Description |
Attaches the virus to host cellular receptor, inducing clathrin-dependent endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane. In neurons, neo-synthesized glycoproteins are sorted to the dendrites, where the virus buds. |
Sequence Annotation |
Topological domain: 17 467 Virion surface.
Transmembrane: 468 488 Helical.
Topological domain: 489 511 Intravirion.
Motif: 496 506 basolateral targeting ex vivo.
|
Protein Length |
511 AA. |
Protein Sequence
(Canonical) |
MKCLLYLAFL FIGVNCKFTI VFPHNQKGNW KNVPSNYHYC PSSSDLNWHN DLIGTAIQVK 60
MPKSHKAIQA DGWMCHASKW VTTCDFRWYG PKYITQSIRS FTPSVEQCKE SIEQTKQGTW 120
LNPGFPPQSC GYATVTDAEA VIVQVTPHHV LVDEYTGEWV DSQFINGKCS NYICPTVHNS 180
TTWHSDYKVK GLCDSNLISM DITFFSEDGE LSSLGKEGTG FRSNYFAYET GGKACKMQYC 240
KHWGVRLPSG VWFEMADKDL FAAARFPECP EGSSISAPSQ TSVDVSLIQD VERILDYSLC 300
QETWSKIRAG LPISPVDLSY LAPKNPGTGP AFTIINGTLK YFETRYIRVD IAAPILSRMV 360
GMISGTTTER ELWDDWAPYE DVEIGPNGVL RTSSGYKFPL YMIGHGMLDS DLHLSSKAQV 420
FEHPHIQDAA SQLPDDESLF FGDTGLSKNP IELVEGWFSS WKSSIASFFF IIGLIIGLFL 480
VLRVGIHLCI KLKHTKKRQI YTDIEMNRLG K 511
|
FASTA
(Canonical) |
>LipidDB-11285-00975|P03522
MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTAIQVK
MPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITQSIRSFTPSVEQCKESIEQTKQGTW
LNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNS
TTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYC
KHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSLC
QETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRMV
GMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLSSKAQV
FEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEGWFSSWKSSIASFFFIIGLIIGLFL
VLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK
|
Gene Ontology |
GO:0033644; C:host cell membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0075512; P:clathrin-mediated endocytosis of virus by host cell; IEA:UniProtKB-KW GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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