| Tag |
Content |
LipidDB ID |
LipidDB-10886-00347 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.02 |
Molecular Weight |
76270.67 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Outer capsid protein mu-1C |
Protein Synonyms/Alias |
Mu1; |
Gene Name |
M2 |
Gene Synonyms/Alias |
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Created Date |
01-JUL-1989 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGNASSIVQ | [1] | N-Myristoylation |
|
Organism |
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3) |
NCBI Taxa ID |
10886 |
Reference |
[1] Tillotson L, Shatkin AJ. Reovirus polypeptide sigma 3 and N-terminalmyristoylation of polypeptide mu 1 are required for site-specific cleavage to mu 1C in transfected cells. J Virol. 1992 Apr;66(4):2180-6.[ PMID:1548757]
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Functional Description |
Major outer capsid protein involved in host cell membrane penetration. In the endocytic compartment, outer-capsid protein sigma-3 is removed by cathepsin proteases, which exposes the viral membrane-penetration protein mu-1. Both myristoylated peptides mu-1N and phi are released during infectious subvirion particles (ISVP) formation in the endosome. They associate with host membranes and mu-1N induces permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm. Seems to induce apoptosis in the host cell (By similarity). |
Sequence Annotation |
Functional site: 42 43 Cleavage.
|
Protein Length |
708 AA. |
Protein Sequence
(Canonical) |
MGNASSIVQT INVTGDGNVF KPSAETSSTA VPSLSLSPGM LNPGGVPWIA VGDETSVTSP 60
GALRRMTSKD IPETAIINTD NSSGAVPSES ALVPYIDEPL VVVTEHAITN FTKAEMALEF 120
NREFLDKMRV LSVSPKYSDL LTYVDCYVGV SARQALNNFQ KQVPVITPTR QTMYVDSIQA 180
ALKALEKWEI DLRVAQTLLP TNVPIGEVSC PMQSVVKLLD DQLPDDSLIR RYPKEAAVAL 240
AKRNGGIQWM DVSEGTVMNE AVNAVAASAL APSASAPPLE EKSKLTEQAM DLVTAAEPEI 300
IASLAPVPAP VFAIPPKPAD YNVRTLRIDE ATWLRMIPKS MNTPFQIQVT DNTGTNWHLN 360
LRGGTRVVNL DQIAPMRFVL DLGGKSYKET SWDPNGKKVG FIVFQSKIPF ELWTAASQIG 420
QATVVNYVQL YAEDSSFTAQ SIIATTSLAY NYEPEQLNKT DPEMNYYLLA TFIDSAAITP 480
TNMTQPDVWD ALLTMSPLSA GEVTVKGAVV SEVVPADLIG SYTPESLNAS LPNDAARCMI 540
DRASKIAEAI KIDDDAGPDE YSPNSVPIQG QLAISQLETG YGVRIFNPKG ILSKIASRAM 600
QAFIGDPSTI ITQAAPVLSD KNNWIALAQG VKTSLRTKSL SAGVKTAVSK LSSSESIQNW 660
TQGFLDKVSA HFPAPKPDCP TSGDSGESSN RRVKRDSYAG VVKRGYTR 708
|
FASTA
(Canonical) |
>LipidDB-10886-00347|P11078
MGNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAVGDETSVTSP
GALRRMTSKDIPETAIINTDNSSGAVPSESALVPYIDEPLVVVTEHAITNFTKAEMALEF
NREFLDKMRVLSVSPKYSDLLTYVDCYVGVSARQALNNFQKQVPVITPTRQTMYVDSIQA
ALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVAL
AKRNGGIQWMDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEI
IASLAPVPAPVFAIPPKPADYNVRTLRIDEATWLRMIPKSMNTPFQIQVTDNTGTNWHLN
LRGGTRVVNLDQIAPMRFVLDLGGKSYKETSWDPNGKKVGFIVFQSKIPFELWTAASQIG
QATVVNYVQLYAEDSSFTAQSIIATTSLAYNYEPEQLNKTDPEMNYYLLATFIDSAAITP
TNMTQPDVWDALLTMSPLSAGEVTVKGAVVSEVVPADLIGSYTPESLNASLPNDAARCMI
DRASKIAEAIKIDDDAGPDEYSPNSVPIQGQLAISQLETGYGVRIFNPKGILSKIASRAM
QAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNW
TQGFLDKVSAHFPAPKPDCPTSGDSGESSNRRVKRDSYAGVVKRGYTR
|
Gene Ontology |
GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-KW GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-KW GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016020; C:membrane; IEA:UniProtKB-KW GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW GO:0046812; F:host cell surface binding; IEA:InterPro GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO:0009405; P:pathogenesis; IEA:InterPro GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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