LipidDB ID

LipidDB-10421-00286

Entry Name

UniProt Accession

P0C6L4;

Theoretical PI

9.95

Molecular Weight

24086.18

Genbank Protein ID

CAA42749.1;

Genbank Nucleotide ID

X60193;

Protein Name

Large delta antigen

Protein Synonyms/Alias

L-HDAg; p27;

Gene Name

Gene Synonyms/Alias

Created Date

14-APR-2009

Organism

Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)

NCBI Taxa ID

10421

Reference

[1] O'Malley B, Lazinski DW. Roles of carboxyl-terminal and farnesylated residues in the functions of the large hepatitis delta antigen. J Virol. 2005Jan;79(2):1142-53.[PMID:15613342]

Functional Description

Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity).

Sequence Annotation

Region: 13 60 Dimerization.
Region: 97 107 RNA-binding.
Region: 136 146 RNA-binding.
Motif: 66 75 Nuclear localization signal.
Modified residue: 2 2 Phosphoserine; by host.
Modified residue: 14 14 Omega-N-methylated arginine; by host.
Modified residue: 72 72 N6-acetyllysine; by host.
Modified residue: 123 123 Phosphoserine; by host.
Modified residue: 177 177 Phosphoserine; by host.
Modified residue: 211 211 Cysteine methyl ester; by host.

Protein Length

214 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW
GO:0005622; C:intracellular; IEA:GOC
GO:0019012; C:virion; IEA:UniProtKB-KW
GO:0003723; F:RNA binding; IEA:UniProtKB-KW
GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW
GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW

Interpro

InterPro; IPR027403; Delta_antigen_N
InterPro; IPR002506; HDV_ag

Pfam

Pfam; PF01517; HDV_ag;

SMART

PROSITE

PRINTS