| Tag |
Content |
LipidDB ID |
LipidDB-10254-00066 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.72 |
Molecular Weight |
27279.23 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Protein L1 |
Protein Synonyms/Alias |
Virion membrane protein M25; |
Gene Name |
|
Gene Synonyms/Alias |
VACWR088; L1R; |
Created Date |
01-APR-1988 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGAAASIQT | [1][2] | N-Myristoylation |
|
Organism |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strai WR)) |
NCBI Taxa ID |
10254 |
Reference |
[1] Franke CA, Wilson EM, Hruby DE. Use of a cell-free system to identify thevaccinia virus L1R gene product as the major late myristylated virion proteinM25. J Virol. 1990 Dec;64(12):5988-96.[ PMID:2243383]
[2] Martin KH, Grosenbach DW, Franke CA, Hruby DE. Identification and analysis of three myristylated vaccinia virus late proteins. J Virol. 1997 Jul;71(7):5218-26.[ PMID:9188589]
|
Functional Description |
Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. |
Sequence Annotation |
Topological domain: 2 183 Virion surface.
Transmembrane: 184 204 Helical.
Topological domain: 205 250 Intravirion.
Region: 2 12 Targeting to MV membrane.
|
Protein Length |
250 AA. |
Protein Sequence
(Canonical) |
MGAAASIQTT VNTLSERISS KLEQEANASA QTKCDIEIGN FYIRQNHGCN LTVKNMCSAD 60
ADAQLDAVLS AATETYSGLT PEQKAYVPAM FTAALNIQTS VNTVVRDFEN YVKQTCNSSA 120
VVDNKLKIQN VIIDECYGAP GSPTNLEFIN TGSSKGNCAI KALMQLTTKA TTQIAPKQVA 180
GTGVQFYMIV IGVIILAALF MYYAKRMLFT STNDKIKLIL ANKENVHWTT YMDTFFRTSP 240
MVIATTDMQN 250
|
FASTA
(Canonical) |
>LipidDB-10254-00066|P07612
MGAAASIQTTVNTLSERISSKLEQEANASAQTKCDIEIGNFYIRQNHGCNLTVKNMCSAD
ADAQLDAVLSAATETYSGLTPEQKAYVPAMFTAALNIQTSVNTVVRDFENYVKQTCNSSA
VVDNKLKIQNVIIDECYGAPGSPTNLEFINTGSSKGNCAIKALMQLTTKATTQIAPKQVA
GTGVQFYMIVIGVIILAALFMYYAKRMLFTSTNDKIKLILANKENVHWTTYMDTFFRTSP
MVIATTDMQN
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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