LipidDB ID

LipidDB-10116-01470

Entry Name

UniProt Accession

P23977;

Theoretical PI

6.63

Molecular Weight

68746.24

Genbank Protein ID

AAA41100.1; AAA73143.1; AAB21099.1;

Genbank Nucleotide ID

M80233; M80570; S76145;

Protein Name

Sodium-dependent dopamine transporter

Protein Synonyms/Alias

DA transporter; DAT; Solute carrier family 6 member 3;

Gene Name

Slc6a3

Gene Synonyms/Alias

Created Date

01-MAR-1992

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Foster JD, Vaughan RA. Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation. J Biol Chem. 2011 Feb18;286(7):5175-86. doi: 10.1074/jbc.M110.187872. Epub 2010 Nov 30.[PMID:21118819]

Functional Description

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Sequence Annotation

Topological domain: 1 68 Cytoplasmic.
Transmembrane: 69 89 Helical; Name=1.
Transmembrane: 96 116 Helical; Name=2.
Transmembrane: 140 160 Helical; Name=3.
Topological domain: 161 236 Extracellular.
Transmembrane: 237 255 Helical; Name=4.
Transmembrane: 264 281 Helical; Name=5.
Transmembrane: 317 334 Helical; Name=6.
Transmembrane: 346 367 Helical; Name=7.
Transmembrane: 400 419 Helical; Name=8.
Transmembrane: 446 464 Helical; Name=9.
Transmembrane: 480 500 Helical; Name=10.
Transmembrane: 521 540 Helical; Name=11.
Transmembrane: 559 577 Helical; Name=12.
Topological domain: 578 619 Cytoplasmic.
Region: 560 589 Interaction with TGFB1I1.

Protein Length

619 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IEA:InterPro
GO:0043005; C:neuron projection; IDA:RGD
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:RGD
GO:0035240; F:dopamine binding; IEA:Ensembl
GO:0005329; F:dopamine transmembrane transporter activity; IDA:RGD
GO:0005330; F:dopamine:sodium symporter activity; IDA:RGD
GO:0008144; F:drug binding; IDA:RGD
GO:0002020; F:protease binding; IPI:RGD
GO:0032403; F:protein complex binding; IDA:RGD
GO:0051721; F:protein phosphatase 2A binding; IPI:RGD
GO:0005102; F:receptor binding; IPI:RGD
GO:0021984; P:adenohypophysis development; IEA:Ensembl
GO:0007568; P:aging; IEP:RGD
GO:0098655; P:cation transmembrane transport; IDA:GOC
GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl
GO:0042420; P:dopamine catabolic process; IEA:Ensembl
GO:0015872; P:dopamine transport; IDA:RGD
GO:0007595; P:lactation; IEA:Ensembl
GO:0007626; P:locomotory behavior; IEA:Ensembl
GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl
GO:0060134; P:prepulse inhibition; IEA:Ensembl
GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl
GO:0051591; P:response to cAMP; IDA:RGD
GO:0042220; P:response to cocaine; IEA:Ensembl
GO:0042493; P:response to drug; IEP:RGD
GO:0045471; P:response to ethanol; IDA:RGD
GO:0010039; P:response to iron ion; IEP:RGD
GO:0035094; P:response to nicotine; IEP:RGD
GO:0014070; P:response to organic cyclic compound; IEP:RGD
GO:0007608; P:sensory perception of smell; IEA:Ensembl

Interpro

InterPro; IPR000175; Na/ntran_symport
InterPro; IPR002436; Na/ntran_symport_dopamine

Pfam

Pfam; PF00209; SNF;

SMART

PROSITE

PROSITE; PS00610; NA_NEUROTRAN_SYMP_1;
PROSITE; PS00754; NA_NEUROTRAN_SYMP_2;
PROSITE; PS50267; NA_NEUROTRAN_SYMP_3;

PRINTS

PRINTS; PR01202; DOPTRANSPORT;
PRINTS; PR00176; NANEUSMPORT;