Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01429
Entry Name
UniProt Accession
Theoretical PI
6.29
Molecular Weight
62106.29
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Excitatory amino acid transporter 2
Protein Synonyms/Alias
GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2;
Gene Name
Slc1a2
Gene Synonyms/Alias
Eaat2; Glt1;
Created Date
01-JUL-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
38
Canonical
RNLGMRMCDKLGKNL
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Sequence Annotation
Topological domain: 1 44 Cytoplasmic.
Transmembrane: 45 64 Helical.
Transmembrane: 88 108 Helical.
Transmembrane: 121 142 Helical.
Topological domain: 143 238 Extracellular.
Transmembrane: 239 258 Helical.
Transmembrane: 279 300 Helical.
Transmembrane: 316 338 Helical.
Transmembrane: 405 429 Helical.
Transmembrane: 436 458 Helical.
Modified residue: 538 538 Phosphotyrosine.
Protein Length
573 AA.
Protein Sequence
(Canonical)
MASTEGANNM PKQVEVRMHD SHLSSEEPKH RNLGMRMCDK LGKNLLLSLT VFGVILGAVC  60
GGLLRLAAPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA  120
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL  180
VQACFQQIQT VTKKVLVAPP SEEANTTKAV ISLLNETMNE APEETKIVIK KGLEFKDGMN  240
VLGLIGFFIA FGIAMGKMGE QAKLMVEFFN ILNEIVMKLV IMIMWYSPLG IACLICGKII  300
AIKDLEVVAR QLGMYMITVI VGLIIHGGIF LPLIYFVVTR KNPFSFFAGI FQAWITALGT  360
ASSAGTLPVT FRCLEDNLGI DKRVTRFVLP VGATINMDGT ALYEAVAAIF IAQMNGVILD  420
GGQIVTVSLT ATLASIGAAS IPSAGLVTML LILTAVGLPT EDISLLVAVD WLLDRMRTSV  480
NVVGDSFGAG IVYHLSKSEL DTIDSQHRMH EDIEMTKTQS VYDDTKNHRE SNSNQCVYAA  540
HNSVVIDECK VTLAANGKSA DCSVEEEPWK REK                               573
FASTA
(Canonical)
>LipidDB-10116-01429|P31596
MASTEGANNMPKQVEVRMHDSHLSSEEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVC
GGLLRLAAPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEETKIVIKKGLEFKDGMN
VLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKII
AIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT
ASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILD
GGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSV
NVVGDSFGAGIVYHLSKSELDTIDSQHRMHEDIEMTKTQSVYDDTKNHRESNSNQCVYAA
HNSVVIDECKVTLAANGKSADCSVEEEPWKREK
Gene Ontology
GO:0043198; C:dendritic shaft; IDA:RGD
GO:0043197; C:dendritic spine; IDA:RGD
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043005; C:neuron projection; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0042734; C:presynaptic membrane; IDA:RGD
GO:0045202; C:synapse; IDA:RGD
GO:0005314; F:high-affinity glutamate transmembrane transporter activity; IMP:RGD
GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro
GO:0015813; P:L-glutamate transport; IMP:RGD
GO:0006836; P:neurotransmitter transport; TAS:RGD
Interpro
InterPro; IPR001991; Na-dicarboxylate_symporter
InterPro; IPR018107; Na-dicarboxylate_symporter_CS
Pfam
Pfam; PF00375; SDF;
SMART
PROSITE
PROSITE; PS00713; NA_DICARBOXYL_SYMP_1;
PROSITE; PS00714; NA_DICARBOXYL_SYMP_2;
PRINTS
PRINTS; PR00173; EDTRNSPORT;