LipidDB ID

LipidDB-10116-01399

Entry Name

UniProt Accession

Q9Z1W6;

Theoretical PI

9.31

Molecular Weight

63969.1

Genbank Protein ID

AAC72405.2;

Genbank Nucleotide ID

AF100421;

Protein Name

Protein LYRIC

Protein Synonyms/Alias

Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein;

Gene Name

Mtdh

Gene Synonyms/Alias

Lyric;

Created Date

21-DEC-2004

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Predicted from GPS-Lipid

Functional Description

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity).

Sequence Annotation

Topological domain: 1 49 Lumenal.
Transmembrane: 50 70 Helical.
Topological domain: 71 581 Cytoplasmic.
Region: 1 71 Activation of NF-kappa-B.
Region: 72 168 Interaction with BCCIP.
Region: 100 204 Interaction with RELA.
Region: 380 442 Lung-homing for mammary tumors.
Modified residue: 142 142 Phosphothreonine.
Modified residue: 263 263 N6-acetyllysine.
Modified residue: 297 297 Phosphoserine.
Modified residue: 305 305 Phosphoserine.
Modified residue: 310 310 Phosphoserine.
Modified residue: 343 343 Phosphoserine.
Modified residue: 368 368 Phosphoserine.
Modified residue: 414 414 Phosphoserine.
Modified residue: 425 425 Phosphoserine.
Modified residue: 567 567 Phosphoserine.

Protein Length

581 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; IDA:RGD
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB
GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0046581; C:intercellular canaliculus; IDA:RGD
GO:0016604; C:nuclear body; IEA:Ensembl
GO:0005730; C:nucleolus; IEA:Ensembl
GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB
GO:0005923; C:tight junction; IDA:RGD
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl
GO:0051059; F:NF-kappaB binding; ISS:UniProtKB
GO:0044822; F:poly(A) RNA binding; IEA:Ensembl
GO:0003713; F:transcription coactivator activity; IEA:Ensembl
GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB
GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl
GO:0010508; P:positive regulation of autophagy; IEA:Ensembl
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB
GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl
GO:0070830; P:tight junction assembly; IEP:RGD

Interpro

Pfam

SMART

PROSITE

PRINTS