| Tag |
Content |
LipidDB ID |
LipidDB-10116-01295 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
5.55 |
Molecular Weight |
140934.52 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Neural cell adhesion molecule L1 |
Protein Synonyms/Alias |
N-CAM-L1; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; NILE; CD171; |
Gene Name |
L1cam |
Gene Synonyms/Alias |
Caml1; |
Created Date |
01-FEB-1994 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
14 | Canonical | YVLPLLLCSPCLLIQ | [1] | S-Palmitoylation | 17 | Canonical | PLLLCSPCLLIQIPD | [1] | S-Palmitoylation | 1143 | Canonical | LLILLILCFIKRSKG | [1] | S-Palmitoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. |
Sequence Annotation |
Topological domain: 20 1122 Extracellular.
Transmembrane: 1123 1145 Helical.
Topological domain: 1146 1259 Cytoplasmic.
Domain: 35 128 Ig-like C2-type 1.
Domain: 138 225 Ig-like C2-type 2.
Domain: 239 327 Ig-like C2-type 3.
Domain: 332 419 Ig-like C2-type 4.
Domain: 424 506 Ig-like C2-type 5.
Domain: 517 600 Ig-like C2-type 6.
Domain: 613 711 Fibronectin type-III 1.
Domain: 716 809 Fibronectin type-III 2.
Domain: 811 916 Fibronectin type-III 3.
Domain: 919 1014 Fibronectin type-III 4.
Domain: 1016 1116 Fibronectin type-III 5.
Motif: 553 555 Cell attachment site.
Motif: 562 564 Cell attachment site.
Modified residue: 1165 1165 Phosphoserine.
Modified residue: 1183 1183 Phosphoserine; by CaMK2.
Modified residue: 1196 1196 Phosphoserine.
Modified residue: 1250 1250 Phosphoserine.
|
Protein Length |
1259 AA. |
Protein Sequence
(Canonical) |
MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT DDISLKCEAR 60
GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN NSFAQRFQGI YRCYASNNLG 120
TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ 180
DERVSMGQNG DLYFANVLTS DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR 240
LLFPTNSSSH LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN 300
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR LDCQVQGRPQ 360
PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV TQCEARNQHG LLLANAYIYV 420
VQLPARILTK DNQTYMAVEG STAYLLCKAF GAPVPSVQWL DEEGTTVLQD ERFFPYANGH 480
LGIRDLQAND TGRYFCQAAN DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA 540
SFDPSLQASI TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE 600
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE FEDKEMAPEK 660
WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS PVSETVVTPE AAPEKNPVDV 720
RGEGNETNNM VITWKPLRWM DWNAPQIQYR VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF 780
VPYEIKVQAV NNQGKGPEPQ VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV 840
KGHLRGYNVT YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR 900
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY LLSYHPLDGE 960
SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP GEAIVREGGT MALFGKPDFG 1020
NISVTAGENY SVVSWVPREG QCNFRFHILF KALPEGKVSP DHQPQPQYVS YNQSSYTQWD 1080
LQPDTKYEIH LMREKVLLHH LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL 1140
ILCFIKRSKG GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD 1200
IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS PINPAVALE 1259
|
FASTA
(Canonical) |
>LipidDB-10116-01295|Q05695
MVMMLWYVLPLLLCSPCLLIQIPDEYKGHHVLEPPVITEQSPRRLVVFPTDDISLKCEAR
GRPQVEFRWTKDGIHFKPKEELGVVVHEAPYSGSFTIEGNNSFAQRFQGIYRCYASNNLG
TAMSHEIQLVAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAAPLRIYWMNSKILHIKQ
DERVSMGQNGDLYFANVLTSDNHSDYICNAHFPGTRTIIQKEPIDLRVKPTNSMIDRKPR
LLFPTNSSSHLVALQGQSLILECIAEGFPTPTIKWLHPSDPMPTDRVIYQNHNKTLQLLN
VGEEDDGEYTCLAENSLGSARHAYYVTVEAAPYWLQKPQSHLYGPGETARLDCQVQGRPQ
PEVTWRINGMSIEKVNKDQKYRIEQGSLILSNVQPSDTMVTQCEARNQHGLLLANAYIYV
VQLPARILTKDNQTYMAVEGSTAYLLCKAFGAPVPSVQWLDEEGTTVLQDERFFPYANGH
LGIRDLQANDTGRYFCQAANDQNNVTILANLQVKEATQITQGPRSTIEKKGARVTFTCQA
SFDPSLQASITWRGDGRDLQERGDSDKYFIEDGQLVIKSLDYSDQGDYSCVASTELDEVE
SRAQLLVVGSPGPVPHLELSDRHLLKQSQVHLSWSPAEDHNSPIEKYDIEFEDKEMAPEK
WFSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV
RGEGNETNNMVITWKPLRWMDWNAPQIQYRVQWRPLGKQETWKEQTVSDPFLVVSNTSTF
VPYEIKVQAVNNQGKGPEPQVTIGYSGEDYPQVSPELEDITIFNSSTVLVRWRPVDLAQV
KGHLRGYNVTYWWKGSQRKHSKRHVHKSHMVVPANTTSAILSGLRPYSSYHVEVQAFNGR
GLGPASEWTFSTPEGVPGHPEALHLECQSDTSLLLHWQPPLSHNGVLTGYLLSYHPLDGE
SKEQLFFNLSDPELRTHNLTNLNPDLQYRFQLQATTHQGPGEAIVREGGTMALFGKPDFG
NISVTAGENYSVVSWVPREGQCNFRFHILFKALPEGKVSPDHQPQPQYVSYNQSSYTQWD
LQPDTKYEIHLMREKVLLHHLAVKTNGTGPVRVSTTGSFASEGWFIAFVSAIILLLLILL
ILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGD
IKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
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Gene Ontology |
GO:0005768; C:endosome; TAS:Reactome GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0045121; C:membrane raft; IDA:RGD GO:0005886; C:plasma membrane; TAS:Reactome GO:0030165; F:PDZ domain binding; IPI:RGD GO:0007155; P:cell adhesion; IEA:UniProtKB-KW GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO:0071361; P:cellular response to ethanol; IEP:RGD GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD GO:0007399; P:nervous system development; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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