Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01224
Entry Name
UniProt Accession
Theoretical PI
6.16
Molecular Weight
21258.61
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cell division control protein 42 homolog
Protein Synonyms/Alias
Gene Name
Cdc42
Gene Synonyms/Alias
Created Date
09-JAN-2007
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
6
Canonical
**MQTIKCVVVGDGA
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity).
Sequence Annotation
Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 115 118 GTP.
Motif: 32 40 Effector region.
Modified residue: 64 64 Phosphotyrosine; by SRC.
Modified residue: 188 188 Cysteine methyl ester.
Protein Length
191 AA.
Protein Sequence
(Canonical)
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG  60
QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR  120
DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP  180
EPKKSRRCVL L                                                       191
FASTA
(Canonical)
>LipidDB-10116-01224|Q8CFN2
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
Gene Ontology
GO:0045177; C:apical part of cell; IEA:Ensembl
GO:0005911; C:cell-cell junction; IEA:Ensembl
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0030175; C:filopodium; IEA:Ensembl
GO:0000139; C:Golgi membrane; IDA:BHF-UCL
GO:0031256; C:leading edge membrane; IEA:Ensembl
GO:0016020; C:membrane; ISS:UniProtKB
GO:0030496; C:midbody; ISS:UniProtKB
GO:0072686; C:mitotic spindle; ISS:UniProtKB
GO:0043005; C:neuron projection; IEA:Ensembl
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0030141; C:secretory granule; IDA:UniProtKB
GO:0051233; C:spindle midzone; ISS:UniProtKB
GO:0005525; F:GTP binding; TAS:UniProtKB
GO:0003924; F:GTPase activity; TAS:RGD
GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD
GO:0090135; P:actin filament branching; IMP:RGD
GO:0051017; P:actin filament bundle assembly; IEA:Ensembl
GO:0007015; P:actin filament organization; IMP:RGD
GO:0034332; P:adherens junction organization; IEA:Ensembl
GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl
GO:0003161; P:cardiac conduction system development; IEA:Ensembl
GO:0034613; P:cellular protein localization; IEA:Ensembl
GO:0036336; P:dendritic cell migration; IEA:Ensembl
GO:0090136; P:epithelial cell-cell adhesion; IEA:Ensembl
GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl
GO:0030010; P:establishment of cell polarity; TAS:RGD
GO:0051683; P:establishment of Golgi localization; IMP:BHF-UCL
GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IEA:Ensembl
GO:0046847; P:filopodium assembly; IEA:Ensembl
GO:0007030; P:Golgi organization; IMP:BHF-UCL
GO:0006184; P:GTP catabolic process; TAS:GOC
GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl
GO:0060789; P:hair follicle placode formation; IEA:Ensembl
GO:0060047; P:heart contraction; IEA:Ensembl
GO:0031424; P:keratinization; IEA:Ensembl
GO:0003334; P:keratinocyte development; IEA:Ensembl
GO:0035264; P:multicellular organism growth; IEA:Ensembl
GO:0010629; P:negative regulation of gene expression; IEA:Ensembl
GO:0031333; P:negative regulation of protein complex assembly; IEA:Ensembl
GO:0048664; P:neuron fate determination; IEA:Ensembl
GO:0007097; P:nuclear migration; IEA:Ensembl
GO:0051647; P:nucleus localization; IEA:Ensembl
GO:0072384; P:organelle transport along microtubule; IMP:BHF-UCL
GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB
GO:0045740; P:positive regulation of DNA replication; IMP:RGD
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl
GO:0071338; P:positive regulation of hair follicle cell proliferation; IEA:Ensembl
GO:0090316; P:positive regulation of intracellular protein transport; IMP:RGD
GO:0046330; P:positive regulation of JNK cascade; IDA:RGD
GO:0048554; P:positive regulation of metalloenzyme activity; IMP:RGD
GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl
GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Ensembl
GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB
GO:0051835; P:positive regulation of synapse structural plasticity; IMP:RGD
GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB
GO:0017157; P:regulation of exocytosis; TAS:UniProtKB
GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB
GO:0007088; P:regulation of mitosis; IEA:Ensembl
GO:0042176; P:regulation of protein catabolic process; IEA:Ensembl
GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl
GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl
GO:0031647; P:regulation of protein stability; IEA:Ensembl
GO:0009749; P:response to glucose; TAS:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0002040; P:sprouting angiogenesis; IMP:RGD
GO:0060661; P:submandibular salivary gland formation; IEP:RGD
GO:0021762; P:substantia nigra development; IEA:Ensembl
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00174; RHO;
PROSITE
PROSITE; PS51420; RHO;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;