| Tag |
Content |
LipidDB ID |
LipidDB-10116-01213 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
7.62 |
Molecular Weight |
418423.8 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Protein bassoon |
Protein Synonyms/Alias |
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Gene Name |
Bsn |
Gene Synonyms/Alias |
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Created Date |
16-AUG-2004 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGNEASLEG | [1] | N-Myristoylation |
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Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Dresbach T, Hempelmann A, Spilker C, tom Dieck S, Altrock WD, Zuschratter W,Garner CC, Gundelfinger ED. Functional regions of the presynaptic cytomatrixprotein bassoon: significance for synaptic targeting and cytomatrix anchoring.Mol Cell Neurosci. 2003 Jun;23(2):279-91.[ PMID:12812759]
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Functional Description |
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity). |
Sequence Annotation |
Region: 62 70 4 X 2 AA tandem repeats of P-G.
Region: 568 588 3 X 7 AA tandem repeats of K-A-S-P-Q-A-[AK].
Region: 2934 2996 Sufficient for binding to ERC2.
Modified residue: 1093 1093 Phosphoserine.
Modified residue: 1221 1221 Phosphoserine.
Modified residue: 2564 2564 Phosphoserine.
Modified residue: 2581 2581 Phosphothreonine.
Modified residue: 2608 2608 Phosphothreonine.
Modified residue: 3368 3368 Phosphoserine.
|
Protein Length |
3938 AA. |
Protein Sequence
(Canonical) |
MGNEASLEGG AGEGPLPPGG SGLGPGPGAG KPPSALAGGG QLPVAGAARA AGPPTPGLGL 60
VPGPGPGPGP GSVSRRLDPK EPLGSQRATS PTPKQASATA PGRESPRETR AQGLSGQEAE 120
GPRRTLQVDS RTQRSGRSPS VSPDRGSTPT SPYSVPQIAP LPSSTLCPIC KTSDLTSTSS 180
QPNFNTCTQC HNKVCNQCGF NPNPHLTQVK EWLCLNCQMQ RALGMDMTTA PRSKSQQQLH 240
SPALSPAHSP AKQPLGKPEQ ERSRSPGATQ SGPRQAEAAR ATSVPGPTQA TAPPEVGRVS 300
PQPPLSTKPS TAEPRPPAGE AQGKSATTVP SGLGAAEQTQ GGLTGKLFGL GASLLTQAST 360
LMSVQPEADT QGQPSPSKGP PKIVFSDASK EAGPRPPGSG PGPGPTPGAK TEPGPRTGPG 420
SGPGALAKTG GTPSPKHGRA DHQAASKAAA KPKTMPKERA ACPLCQAELN VGSRGPANYN 480
TCTACKLRVC TLCGFNPTPH LVEKTEWLCL NCQTKRLLEG SLGEPAPLPL PTPQEPPAGV 540
PQRAAGASPL KQKGPQGPGQ PSGSLPPKAS PQAAKASPQA AKASPQAKPL RASEPSKTSS 600
SAPEKKTGIP VKAEPVPKPP PETAVPPGTP KAKSGVKRTD PATPVVKPVP EAPKSGEAEE 660
PVPKPYSQDL SRSPQSLSDT GYSSDGVSSS QSEITGVVQQ EVEQLDSAGV TGPRPPSPSE 720
LHKVGSSMRP SLEAQAVAPS GEWSKPPSGS AVEDQKRRPH SLSIMPEAFD SDEELGDILE 780
EDDSLAMGRQ REQQDTAESS DDFGSQLRHD YVEDSSEGGL SPLPPQPPAR ADMTDEEFMR 840
RQILEMSAEE DNLEEDDTAV SGRGLAKHGA QKASARPRPE SSQESVALPK RRLPHNATTG 900
YEELLSEEGP AEPTDGALQG GLRRFKTIGL NSTGRLWSTS LDLGQGSDPN LDREPELEME 960
SLTGSPEDRS RGEHSSTLPA STPSYTSGTS PTSLSSLEED SDSSPSRRQR LEEAKQQRKA 1020
RHRSHGPLLP TIEDSSEEEE LREEEELLRE QEKMREVEQQ RIRSTARKTR RDKEELRAQR 1080
RRERSKTPPS NLSPIEDASP TEELRQAAEM EELHRSSCSE YSPSPSLDSE AETLDGGPTR 1140
LYKSGSEYNL PAFMSLCSPT ETPSGSSTTP SSGRPLKSAE EAYEDMMRKA ELLQRQQGQA 1200
AGARGPHGGP SQPTGPRSQG SFEYQDTLDH DYGGRASQPA ADGTPAGLGA TVYEEILQTS 1260
QSIARMRQAS SRDLAFTEDK KKEKQFLNAE SAYMDPMKQN GGPLTPGTSP TQLAAPVSFP 1320
TSTSSDSSGG RVIPDVRVTQ HFAKEPQEPL KLHSSPASPS LASKEVGMTF SQGPGTPATT 1380
AMAPCPASLP RGYMTPAGPE RSPSTSSTIH SYGQPPTTAN YGSQTEELPH APSGPAGSGR 1440
ASREKPLSGG DGEVGPPQPS RGYSYFTGSS PPLSPSTPSE SPTFSPSKLG PRATAEFSTQ 1500
TPSLTPSSDI PRSVGTPSPM VAQGTQTPHR PSTPRLVWQQ SSQEAPVMVI TLASDASSQT 1560
RMVHASASTS PLCSPTDSQP ASHSYSQTTP PSASQMPSEP AGPPGFPRAP SAGVDGPLAL 1620
YGWGALPAEN ISLCRISSVP GTSRVEPGPR PPGTAVVDLR TAVKPTPIIL TDQGMDLTSL 1680
AVEARKYGLA LDPVPGRQST AVQPLVINLN AQEQTHTFLA TATTVSITMA SSVLMAQQKQ 1740
PVVYGDPFQS RLDFGQGSGS PVCLAQVKQV EQAVQTAPYR GGPRGRPREA KFARYNLPNQ 1800
VTPLARRDIL ITQMGTAQSV SLKPGPVPEP GAEPHRATPA ELRAHALPGT RKPHTVVVQM 1860
GEGAAGTVTT LLPEEPAGAL DLTGMRPESR LACCDMAYKF PFGSSCTGTF HPAPSAPDKS 1920
VTDAALPGQS SGPFYSPRDP EPPEPLTFRA QGVVGPGPHE EQRPYPQGLP GRLYSSMSDT 1980
NLAEAGLNYH AQRIGQLFQG PGRDSAVDLS SLKHSYSLGF ADGRYLGQGL QYGSFTDLRH 2040
PTDLLSHPLP MRPYSSVSNI YSDHRYGPRG DAVGFQEASL AQYSATTARE ISRMCAALNS 2100
MDQYGGRHGG GSGGPDLVPY QPQHGPGLNA PQGLASLRSG LLGNPTYPEG QPSPGNLAQY 2160
GPAASQGTAV RQLLPSTATV RAADGMIYST INTPIAATLP ITTQPASVLR PMVRGGMYRP 2220
YGSGGVTAVP LTSLTRVPMI APRVPLGPAG LYRYPAPSRF PIASTIPPAE GPVYLGKPAA 2280
AKASGAGGPP RPELPAGGAR EEPLSTTAPP AVIKEAPVAQ APAPPPGQKP AGDAAAGSGS 2340
GVLGRPVMEK EEASQEDRQR KQQEQLLQLE RERVELEKLR QLRLQEELER ERVELQRHRE 2400
EEQLLVQREL QELQTIKHHV LQQQQEERQA QFALQREQLA QQRLQLEQIQ QLQQQLQQQL 2460
EEQKQRQKAP FPATCEAPSR GPPPAATELA QNGQYWPPLT HTAFIAVAGT EGPGQAREPV 2520
LHRGLPSSAS DMSLQTEEQW EAGRSGIKKR HSMPRLRDAC EPESGPDPST VRRIADSSVQ 2580
TDDEEGEGRY LLTRRRRTRR SADCSVQTDD EDNAEWEQPV RRRRSRLSRH SDSGSDSKHE 2640
ASASSSAAAA AARAMSSVGI QTISDCSVQT EPEQLPRVSP AIHITAATDP KVEIVRYISA 2700
PEKTGRGESL ACQTEPDGQA QGVAGPQLIG PTAISPYLPG IQIVTPGALG RFEKKKPDPL 2760
EIGYQAHLPP ESLSQLVSRQ PPKSPQVLYS PVSPLSPHRL LDTSFASSER LNKAHVSPQK 2820
QFIADSTLRQ QTLPRPMKTL QRSLSDPKPL SPTAEESAKE RFSLYQHQGG LGSQVSALPP 2880
NGLVRKVKRT LPSPPPEEAH LPLAGQVPSQ LYAASLLQRG LAGPTTVPAT KASLLRELDR 2940
DLRLVEHEST KLRKKQAELD EEEKEIDAKL KYLELGITQR KESLAKDRVG RDYPPLRGLG 3000
EHRDYLSDSE LNQLRLQGCT TPAGQYVDYP ASAAVPATPS GPTAFQQPRF PPAATQYTAG 3060
SSGPTQNGFL AHQAPTYTGP STYPAPTYPP GTSYPAEPGL PSQPAFHPTG HYAAPTPMPT 3120
TQSAPFPVQA DSHAAHQKPR QTSLADLEQK VPTNYEVISS PAVTVSSTPS ETGYSGPAVS 3180
SSYEHGKAPE HPRGGDRSSV SQSPAPTYPS DSHYTSLEQN VPRNYVMIDD ISELTKDSTP 3240
TASDSQRPEP LGPGGVSGRP GKDPGEPAVL EGPTLPCCYG RGEEESEEDS YDPRGKSGHH 3300
RSMESNGRPA STHYYSDSDY RHGARADKYG PGPMGPKHPS KNLAPAAISS KRSKHRKQGM 3360
EQKISKFSPI EEAKDVESDL ASYPPPTVSS SLTSRSRKFQ DEITYGLKKN VYEQQRYYGV 3420
SSRDTAEEDD RMYGGSSRSR VASAYSGEKL SSHDFSSRSK GYERERETAQ RLQKAGPKPS 3480
SLSMAHGRAR PPMRSQASEE ESPVSPLGRP RPAGGALPPG DTCPQFCSSH SMPDVQEHVK 3540
DGPRAHAYKR EEGYILDDSH CVVSDSEAYH LGQEETDWFD KPRDARSDRF RHHGGHTVSS 3600
SQKRGPARHS YHDYDEPPEE GLWPHDEGGP GRHTSAKEHR HHGDHGRHSG RHAGEEPGRR 3660
AARPHARDMG RHETRPHPQA SPAPAMQKKG QPGYPSSADY SQPSRAPSAY HHASDSKKGS 3720
RQAHSGPTVL QPKPEAQAQP QMQGRQAVPG PQQSQPPSSR QTPSGTASRQ PQTQQQQQQQ 3780
QQQQQQQQQQ QQQQQQQGLG QQAPQQAPSQ ARLQQQSQPT TRSTAPAASH PAGKPQPGPT 3840
TAPGPQPAGL PRAEQAGSSK PAAKAPQQGR APQAQSAPGP AGAKTGARPG GTPGAPAGQP 3900
AAEGESVFSK ILPGGAAEQA GKLTEAVSAF GKKFSSFW 3938
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FASTA
(Canonical) |
>LipidDB-10116-01213|O88778
MGNEASLEGGAGEGPLPPGGSGLGPGPGAGKPPSALAGGGQLPVAGAARAAGPPTPGLGL
VPGPGPGPGPGSVSRRLDPKEPLGSQRATSPTPKQASATAPGRESPRETRAQGLSGQEAE
GPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLPSSTLCPICKTSDLTSTSS
QPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLH
SPALSPAHSPAKQPLGKPEQERSRSPGATQSGPRQAEAARATSVPGPTQATAPPEVGRVS
PQPPLSTKPSTAEPRPPAGEAQGKSATTVPSGLGAAEQTQGGLTGKLFGLGASLLTQAST
LMSVQPEADTQGQPSPSKGPPKIVFSDASKEAGPRPPGSGPGPGPTPGAKTEPGPRTGPG
SGPGALAKTGGTPSPKHGRADHQAASKAAAKPKTMPKERAACPLCQAELNVGSRGPANYN
TCTACKLRVCTLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLGEPAPLPLPTPQEPPAGV
PQRAAGASPLKQKGPQGPGQPSGSLPPKASPQAAKASPQAAKASPQAKPLRASEPSKTSS
SAPEKKTGIPVKAEPVPKPPPETAVPPGTPKAKSGVKRTDPATPVVKPVPEAPKSGEAEE
PVPKPYSQDLSRSPQSLSDTGYSSDGVSSSQSEITGVVQQEVEQLDSAGVTGPRPPSPSE
LHKVGSSMRPSLEAQAVAPSGEWSKPPSGSAVEDQKRRPHSLSIMPEAFDSDEELGDILE
EDDSLAMGRQREQQDTAESSDDFGSQLRHDYVEDSSEGGLSPLPPQPPARADMTDEEFMR
RQILEMSAEEDNLEEDDTAVSGRGLAKHGAQKASARPRPESSQESVALPKRRLPHNATTG
YEELLSEEGPAEPTDGALQGGLRRFKTIGLNSTGRLWSTSLDLGQGSDPNLDREPELEME
SLTGSPEDRSRGEHSSTLPASTPSYTSGTSPTSLSSLEEDSDSSPSRRQRLEEAKQQRKA
RHRSHGPLLPTIEDSSEEEELREEEELLREQEKMREVEQQRIRSTARKTRRDKEELRAQR
RRERSKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSPSLDSEAETLDGGPTR
LYKSGSEYNLPAFMSLCSPTETPSGSSTTPSSGRPLKSAEEAYEDMMRKAELLQRQQGQA
AGARGPHGGPSQPTGPRSQGSFEYQDTLDHDYGGRASQPAADGTPAGLGATVYEEILQTS
QSIARMRQASSRDLAFTEDKKKEKQFLNAESAYMDPMKQNGGPLTPGTSPTQLAAPVSFP
TSTSSDSSGGRVIPDVRVTQHFAKEPQEPLKLHSSPASPSLASKEVGMTFSQGPGTPATT
AMAPCPASLPRGYMTPAGPERSPSTSSTIHSYGQPPTTANYGSQTEELPHAPSGPAGSGR
ASREKPLSGGDGEVGPPQPSRGYSYFTGSSPPLSPSTPSESPTFSPSKLGPRATAEFSTQ
TPSLTPSSDIPRSVGTPSPMVAQGTQTPHRPSTPRLVWQQSSQEAPVMVITLASDASSQT
RMVHASASTSPLCSPTDSQPASHSYSQTTPPSASQMPSEPAGPPGFPRAPSAGVDGPLAL
YGWGALPAENISLCRISSVPGTSRVEPGPRPPGTAVVDLRTAVKPTPIILTDQGMDLTSL
AVEARKYGLALDPVPGRQSTAVQPLVINLNAQEQTHTFLATATTVSITMASSVLMAQQKQ
PVVYGDPFQSRLDFGQGSGSPVCLAQVKQVEQAVQTAPYRGGPRGRPREAKFARYNLPNQ
VTPLARRDILITQMGTAQSVSLKPGPVPEPGAEPHRATPAELRAHALPGTRKPHTVVVQM
GEGAAGTVTTLLPEEPAGALDLTGMRPESRLACCDMAYKFPFGSSCTGTFHPAPSAPDKS
VTDAALPGQSSGPFYSPRDPEPPEPLTFRAQGVVGPGPHEEQRPYPQGLPGRLYSSMSDT
NLAEAGLNYHAQRIGQLFQGPGRDSAVDLSSLKHSYSLGFADGRYLGQGLQYGSFTDLRH
PTDLLSHPLPMRPYSSVSNIYSDHRYGPRGDAVGFQEASLAQYSATTAREISRMCAALNS
MDQYGGRHGGGSGGPDLVPYQPQHGPGLNAPQGLASLRSGLLGNPTYPEGQPSPGNLAQY
GPAASQGTAVRQLLPSTATVRAADGMIYSTINTPIAATLPITTQPASVLRPMVRGGMYRP
YGSGGVTAVPLTSLTRVPMIAPRVPLGPAGLYRYPAPSRFPIASTIPPAEGPVYLGKPAA
AKASGAGGPPRPELPAGGAREEPLSTTAPPAVIKEAPVAQAPAPPPGQKPAGDAAAGSGS
GVLGRPVMEKEEASQEDRQRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHRE
EEQLLVQRELQELQTIKHHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQQQL
EEQKQRQKAPFPATCEAPSRGPPPAATELAQNGQYWPPLTHTAFIAVAGTEGPGQAREPV
LHRGLPSSASDMSLQTEEQWEAGRSGIKKRHSMPRLRDACEPESGPDPSTVRRIADSSVQ
TDDEEGEGRYLLTRRRRTRRSADCSVQTDDEDNAEWEQPVRRRRSRLSRHSDSGSDSKHE
ASASSSAAAAAARAMSSVGIQTISDCSVQTEPEQLPRVSPAIHITAATDPKVEIVRYISA
PEKTGRGESLACQTEPDGQAQGVAGPQLIGPTAISPYLPGIQIVTPGALGRFEKKKPDPL
EIGYQAHLPPESLSQLVSRQPPKSPQVLYSPVSPLSPHRLLDTSFASSERLNKAHVSPQK
QFIADSTLRQQTLPRPMKTLQRSLSDPKPLSPTAEESAKERFSLYQHQGGLGSQVSALPP
NGLVRKVKRTLPSPPPEEAHLPLAGQVPSQLYAASLLQRGLAGPTTVPATKASLLRELDR
DLRLVEHESTKLRKKQAELDEEEKEIDAKLKYLELGITQRKESLAKDRVGRDYPPLRGLG
EHRDYLSDSELNQLRLQGCTTPAGQYVDYPASAAVPATPSGPTAFQQPRFPPAATQYTAG
SSGPTQNGFLAHQAPTYTGPSTYPAPTYPPGTSYPAEPGLPSQPAFHPTGHYAAPTPMPT
TQSAPFPVQADSHAAHQKPRQTSLADLEQKVPTNYEVISSPAVTVSSTPSETGYSGPAVS
SSYEHGKAPEHPRGGDRSSVSQSPAPTYPSDSHYTSLEQNVPRNYVMIDDISELTKDSTP
TASDSQRPEPLGPGGVSGRPGKDPGEPAVLEGPTLPCCYGRGEEESEEDSYDPRGKSGHH
RSMESNGRPASTHYYSDSDYRHGARADKYGPGPMGPKHPSKNLAPAAISSKRSKHRKQGM
EQKISKFSPIEEAKDVESDLASYPPPTVSSSLTSRSRKFQDEITYGLKKNVYEQQRYYGV
SSRDTAEEDDRMYGGSSRSRVASAYSGEKLSSHDFSSRSKGYERERETAQRLQKAGPKPS
SLSMAHGRARPPMRSQASEEESPVSPLGRPRPAGGALPPGDTCPQFCSSHSMPDVQEHVK
DGPRAHAYKREEGYILDDSHCVVSDSEAYHLGQEETDWFDKPRDARSDRFRHHGGHTVSS
SQKRGPARHSYHDYDEPPEEGLWPHDEGGPGRHTSAKEHRHHGDHGRHSGRHAGEEPGRR
AARPHARDMGRHETRPHPQASPAPAMQKKGQPGYPSSADYSQPSRAPSAYHHASDSKKGS
RQAHSGPTVLQPKPEAQAQPQMQGRQAVPGPQQSQPPSSRQTPSGTASRQPQTQQQQQQQ
QQQQQQQQQQQQQQQQQGLGQQAPQQAPSQARLQQQSQPTTRSTAPAASHPAGKPQPGPT
TAPGPQPAGLPRAEQAGSSKPAAKAPQQGRAPQAQSAPGPAGAKTGARPGGTPGAPAGQP
AAEGESVFSKILPGGAAEQAGKLTEAVSAFGKKFSSFW
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Gene Ontology |
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Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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