Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01180
Entry Name
UniProt Accession
Theoretical PI
8.58
Molecular Weight
52845.02
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cannabinoid receptor 1
Protein Synonyms/Alias
CB-R; CB1; Brain-type cannabinoid receptor;
Gene Name
Cnr1
Gene Synonyms/Alias
Skr6;
Created Date
01-FEB-1991
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
416
Canonical
FRSMFPSCEGTAQPL
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Oddi S, Dainese E, Sandiford S, Fezza F, Lanuti M, Chiurchiù V, Totaro A,Catanzaro G, Barcaroli D, De Laurenzi V, Centonze D, Mukhopadhyay S, Selent J,Howlett AC, Maccarrone M. Effects of palmitoylation of Cys(415) in helix 8 of theCB(1) cannabinoid receptor on membrane localization and signalling. Br JPharmacol. 2012 Apr;165(8):2635-51. doi: 10.1111/j.1476-5381.2011.01658.x. PubMedPMID: 21895628; PubMed Central PMCID: PMC3423250.[PMID:21895628]
Functional Description
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current.
Sequence Annotation
Topological domain: 1 117 Extracellular.
Transmembrane: 118 143 Helical; Name=1.
Topological domain: 144 155 Cytoplasmic.
Transmembrane: 156 176 Helical; Name=2.
Topological domain: 177 188 Extracellular.
Transmembrane: 189 213 Helical; Name=3.
Topological domain: 214 233 Cytoplasmic.
Transmembrane: 234 256 Helical; Name=4.
Topological domain: 257 274 Extracellular.
Transmembrane: 275 300 Helical; Name=5.
Topological domain: 301 345 Cytoplasmic.
Transmembrane: 346 366 Helical; Name=6.
Topological domain: 367 378 Extracellular.
Transmembrane: 379 400 Helical; Name=7.
Topological domain: 401 473 Cytoplasmic.
Protein Length
473 AA.
Protein Sequence
(Canonical)
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE  60
KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEENIQCG ENFMDMECFM ILNPSQQLAI  120
AVLSLTLGTF TVLENLLVLC VILHSRSLRC RPSYHFIGSL AVADLLGSVI FVYSFVDFHV  180
FHRKDSPNVF LFKLGGVTAS FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL  240
MWTIAIVIAV LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW  300
KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL VVLIICWGPL  360
LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL RSKDLRHAFR SMFPSCEGTA  420
QPLDNSMGDS DCLHKHANNT ASMHRAAESC IKSTVKIAKV TMSVSTDTSA EAL         473
FASTA
(Canonical)
>LipidDB-10116-01180|P20272
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAI
AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHV
FHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCL
MWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILW
KAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPL
LAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004949; F:cannabinoid receptor activity; IMP:RGD
GO:0008144; F:drug binding; IMP:RGD
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; ISS:UniProtKB
GO:0007568; P:aging; IMP:RGD
GO:0038171; P:cannabinoid signaling pathway; IMP:GOC
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD
GO:0042593; P:glucose homeostasis; IEA:Ensembl
GO:0007611; P:learning or memory; IMP:RGD
GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD
GO:0007613; P:memory; IDA:RGD
GO:0045759; P:negative regulation of action potential; IMP:RGD
GO:0045776; P:negative regulation of blood pressure; IMP:RGD
GO:0033602; P:negative regulation of dopamine secretion; IMP:RGD
GO:0031999; P:negative regulation of fatty acid beta-oxidation; IMP:RGD
GO:0043271; P:negative regulation of ion transport; IDA:RGD
GO:0033004; P:negative regulation of mast cell activation; IDA:RGD
GO:0051001; P:negative regulation of nitric-oxide synthase activity; IMP:RGD
GO:0002866; P:positive regulation of acute inflammatory response to antigenic stimulus; IMP:RGD
GO:0043065; P:positive regulation of apoptotic process; IMP:RGD
GO:0045777; P:positive regulation of blood pressure; IMP:RGD
GO:0031622; P:positive regulation of fever generation; IMP:RGD
GO:0010976; P:positive regulation of neuron projection development; IDA:RGD
GO:0060259; P:regulation of feeding behavior; IMP:RGD
GO:0050796; P:regulation of insulin secretion; IMP:RGD
GO:0019216; P:regulation of lipid metabolic process; IMP:RGD
GO:0060405; P:regulation of penile erection; IMP:RGD
GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:RGD
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:RGD
GO:0042220; P:response to cocaine; IMP:RGD
GO:0045471; P:response to ethanol; IMP:RGD
GO:0032496; P:response to lipopolysaccharide; IMP:RGD
GO:0043278; P:response to morphine; IMP:RGD
GO:0035094; P:response to nicotine; IMP:RGD
GO:0007584; P:response to nutrient; IEP:RGD
GO:0019233; P:sensory perception of pain; IMP:RGD
GO:0007283; P:spermatogenesis; IEP:RGD
Interpro
InterPro; IPR000810; Canbinoid_rcpt_1
InterPro; IPR002230; Cnbnoid_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00522; CANABINOID1R;
PRINTS; PR00362; CANNABINOIDR;
PRINTS; PR00237; GPCRRHODOPSN;