Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01092
Entry Name
UniProt Accession
Theoretical PI
4.61
Molecular Weight
23603.34
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Neuromodulin
Protein Synonyms/Alias
Axonal membrane protein GAP-43; Growth-associated protein 43; Protein F1;
Gene Name
Gap43
Gene Synonyms/Alias
Created Date
01-AUG-1988
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
3
Canonical
*****MLCCMRRTKQ
[1]
S-Palmitoylation
4
Canonical
****MLCCMRRTKQV
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Skene JH, Virág I. Posttranslational membrane attachment and dynamic fattyacylation of a neuronal growth cone protein, GAP-43. J Cell Biol. 1989Feb;108(2):613-24.[PMID:2918027]
Functional Description
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
Sequence Annotation
Domain: 31 60 IQ.
Region: 1 4 Important for membrane binding.
Modified residue: 41 41 Phosphoserine; by PHK and PKC.
Modified residue: 96 96 Phosphoserine.
Modified residue: 172 172 Phosphothreonine.
Modified residue: 191 191 Phosphoserine; by CK2.
Modified residue: 192 192 Phosphoserine; by CK2.
Protein Length
226 AA.
Protein Sequence
(Canonical)
MLCCMRRTKQ VEKNDEDQKI EQDGVKPEDK AHKAATKIQA SFRGHITRKK LKDEKKGDAP  60
AAEAEAKEKD DAPVADGVEK KEGDGSATTD AAPATSPKAE EPSKAGDAPS EEKKGEGDAA  120
PSEEKAGSAE TESAAKATTD NSPSSKAEDG PAKEEPKQAD VPAAVTDAAA TTPAAEDAAK  180
AAQPPTETAE SSQAEEEKEA VDEAKPKESA RQDEGKEDPE ADQEHA                 226
FASTA
(Canonical)
>LipidDB-10116-01092|P07936
MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKDEKKGDAP
AAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAA
PSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAAK
AAQPPTETAESSQAEEEKEAVDEAKPKESARQDEGKEDPEADQEHA
Gene Ontology
GO:0030424; C:axon; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0005737; C:cytoplasm; IDA:RGD
GO:0031527; C:filopodium membrane; IEA:Ensembl
GO:0030426; C:growth cone; TAS:RGD
GO:0045202; C:synapse; IEA:UniProtKB-KW
GO:0016198; P:axon choice point recognition; IEA:Ensembl
GO:0045165; P:cell fate commitment; IEA:Ensembl
GO:0010001; P:glial cell differentiation; IEA:Ensembl
GO:0007399; P:nervous system development; IEP:RGD
GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl
GO:0040008; P:regulation of growth; IEA:UniProtKB-KW
GO:0042246; P:tissue regeneration; IEP:RGD
Interpro
InterPro; IPR000048; IQ_motif_EF-hand-BS
InterPro; IPR001422; Neuromodulin
InterPro; IPR017454; Neuromodulin_C
InterPro; IPR018947; Neuromodulin_gap-junction_N
InterPro; IPR018243; Neuromodulin_palmitoyl/P_site
Pfam
Pfam; PF00612; IQ;
Pfam; PF06614; Neuromodulin;
Pfam; PF10580; Neuromodulin_N;
SMART
SMART; SM00015; IQ;
PROSITE
PROSITE; PS50096; IQ;
PROSITE; PS00412; NEUROMODULIN_1;
PROSITE; PS00413; NEUROMODULIN_2;
PRINTS
PRINTS; PR00215; NEUROMODULIN;