Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01088
Entry Name
UniProt Accession
Theoretical PI
5.76
Molecular Weight
71327.04
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cell surface glycoprotein MUC18
Protein Synonyms/Alias
Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18; CD146;
Gene Name
Mcam
Gene Synonyms/Alias
Muc18;
Created Date
10-JAN-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
15
Canonical
CAFLFAACCCCRSAT
[1]
S-Palmitoylation
16
Canonical
AFLFAACCCCRSATG
[1]
S-Palmitoylation
17
Canonical
FLFAACCCCRSATGV
[1]
S-Palmitoylation
18
Canonical
LFAACCCCRSATGVP
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).
Sequence Annotation
Topological domain: 24 560 Extracellular.
Transmembrane: 561 581 Helical.
Topological domain: 582 648 Cytoplasmic.
Domain: 24 131 Ig-like V-type 1.
Domain: 141 244 Ig-like V-type 2.
Domain: 246 332 Ig-like C2-type 1.
Domain: 337 426 Ig-like C2-type 2.
Domain: 432 512 Ig-like C2-type 3.
Modified residue: 616 616 Phosphoserine.
Protein Length
648 AA.
Protein Sequence
(Canonical)
MGLPRLVCAF LFAACCCCRS ATGVPGEEKQ PTPTPDPVEV EVGNTALLKC GPAHPSGNFS  60
QVEWFLIHKE RQIPIFRVHQ GKGQSEPGEY EHRLSLHGPG ATLALSQVTP HDDRMFLCKS  120
KQPRPQDHYV QLQVYKAPEE PTIQANVLGI HVDIQELKEV ATCVGRNGYP IPQVIWYKNG  180
RPLQEEENRV HIQSSQTVES SGLYTLKSVL SARLVKEDKD AQFYCELSYR LPSGNRMKES  240
KEVTVPVLYP AEKVWVEVEP VGLLKEGDHV KIRCLTDGNP QPHFTINKKN PSTEEMEEES  300
TDENGLLSLE PAQKHHSGVY QCQSLDLETT VMLSSDPLEL LVNYVSDVQV DPTAPEVQEG  360
DSLTLTCKAE SNQDLEFEWL RDKTGQLLGK GPILQLNNVK REAGGRYLCV ASVPSVPGLN  420
RTRRVSVGIF GSPWMAAKER KVWAQENAML NLSCEASGHP QPTISWNING SATEWNPDPQ  480
TVVSTLNVLV TPELLETGAE CTASNSLGSN TTVIILKLVT LTTLTPDSSQ TTGLSTPTVS  540
PHSRANSTST EKKLPQQESK GVVIVAVIVC TLVLAVLGAT LYYFYKKGKL PCGRSGKQEI  600
TLPPTRKSEF VVEVKSDKLP EEMALLQGSN GDKRAPGDQG EKYIDLRH               648
FASTA
(Canonical)
>LipidDB-10116-01088|Q9EPF2
MGLPRLVCAFLFAACCCCRSATGVPGEEKQPTPTPDPVEVEVGNTALLKCGPAHPSGNFS
QVEWFLIHKERQIPIFRVHQGKGQSEPGEYEHRLSLHGPGATLALSQVTPHDDRMFLCKS
KQPRPQDHYVQLQVYKAPEEPTIQANVLGIHVDIQELKEVATCVGRNGYPIPQVIWYKNG
RPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNRMKES
KEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRCLTDGNPQPHFTINKKNPSTEEMEEES
TDENGLLSLEPAQKHHSGVYQCQSLDLETTVMLSSDPLELLVNYVSDVQVDPTAPEVQEG
DSLTLTCKAESNQDLEFEWLRDKTGQLLGKGPILQLNNVKREAGGRYLCVASVPSVPGLN
RTRRVSVGIFGSPWMAAKERKVWAQENAMLNLSCEASGHPQPTISWNINGSATEWNPDPQ
TVVSTLNVLVTPELLETGAECTASNSLGSNTTVIILKLVTLTTLTPDSSQTTGLSTPTVS
PHSRANSTSTEKKLPQQESKGVVIVAVIVCTLVLAVLGATLYYFYKKGKLPCGRSGKQEI
TLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
Gene Ontology
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0005615; C:extracellular space; IDA:RGD
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IDA:RGD
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW
GO:0003094; P:glomerular filtration; IEA:Ensembl
GO:0030335; P:positive regulation of cell migration; IDA:RGD
GO:0061042; P:vascular wound healing; IEA:Ensembl
Interpro
InterPro; IPR013162; CD80_C2-set
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
InterPro; IPR003598; Ig_sub2
InterPro; IPR013106; Ig_V-set
Pfam
Pfam; PF08205; C2-set_2;
Pfam; PF07686; V-set;
SMART
SMART; SM00409; IG;
SMART; SM00408; IGc2;
PROSITE
PROSITE; PS50835; IG_LIKE;
PRINTS