| Tag |
Content |
LipidDB ID |
LipidDB-10116-01083 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
6.29 |
Molecular Weight |
112488.48 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Glutamate receptor-interacting protein 2 |
Protein Synonyms/Alias |
GRIP-2; AMPA receptor-interacting protein GRIP2; |
Gene Name |
Grip2 |
Gene Synonyms/Alias |
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Created Date |
29-MAR-2004 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
11 | Isoform 4 | WRRNLALCLQRLPDE | [1][2] | S-Palmitoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] DeSouza S, Fu J, States BA, Ziff EB. Differential palmitoylation directs theAMPA receptor-binding protein ABP to spines or to intracellular clusters. JNeurosci. 2002 May 1;22(9):3493-503.[ PMID:11978826]
[2] Misra C, Restituito S, Ferreira J, Rameau GA, Fu J, Ziff EB. Regulation ofsynaptic structure and function by palmitoylated AMPA receptor binding protein.Mol Cell Neurosci. 2010 Apr;43(4):341-52. doi: 10.1016/j.mcn.2010.01.001. Epub2010 Jan 18.[ PMID:20083202]
|
Functional Description |
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. |
Sequence Annotation |
Domain: 53 136 PDZ 1.
Domain: 153 239 PDZ 2.
Domain: 253 337 PDZ 3.
Domain: 458 547 PDZ 4.
Domain: 559 643 PDZ 5.
Domain: 658 740 PDZ 6.
Domain: 942 1024 PDZ 7.
|
Protein Length |
1043 AA. |
Protein Sequence
(Isoform 4) |
MRGWRRNLAL CLQRLPDEDD GPYSKGGKDT AGTDGALVCR RQSIPEEFRG ITMVELIKRE 60
GSTLGLTISG GTDKDGKPRV SNLRPGGLAA RSDLLNVGDY IRSVNGIRLT RLRHDEIITL 120
LKNVGERVVL EVEYELPPPA PENNPRIISK TVDVSLYKEG NSFGFVLRGG AHEDLHKSRP 180
LVLTYVRPGG PADREGSLKV GDRLLSIDGI PLHGASHATA IATLQQCSHE ALFQVEYDVA 240
TPDTVANASG PLVVEIAKTP GSALGISLTT GSHRNKPAIT IDRIKPASVV DRSGALHAGD 300
HILAIDGTST EHCSLVEATK LLASVTEKVR LEILPAPQSR RPLKPPEAVR IQRSEQLHHW 360
DPCVPSCHSP RPSHCRAPTW APGGQDQSRS VSSTPFSSPT MNPAFPCANA STLPRGPMSP 420
RTTAGRRRQR RKEHRSSLSL ASSTVGPGGQ IVHTETTEVV LCGDPLSGFG LQLQGGIFAT 480
ETLSSPPLVR FIEPDSPAER CGLLQVGDRV LAINGIATED GTMEEANQLL RDAALARKVV 540
LEIEFDVAES VIPSSGTFHV KLPKRRGVEL GITISSASRK RGEPLIISDI KKGSVAHRTG 600
TLEPGDKLLA IDNIRLDHCP MEYAVQILRQ CEDLVKLKIR KDEDNSDEQE SSGAVSYTVE 660
LKRYGGPLGI TISGTEEPFD PIIISGLTKR GLAERTGAIH VGDRILAINS VSLKGRPLSE 720
AIHLLQVAGE TVTLKIKKQL DRPLLPRQSG SLSEASDVDE DPPEALKGGL LTTHFSPAVP 780
SVDSAVESWG SSATEGGFGG SGSYTPQVAV RSVTPQEWRS SRLKSSPPPL EPRRTSYTPG 840
PTDESFPEEE EGDWEPPMSP APGPAREEGF WRVLGEALED LESCGQSELL RELEASIMTG 900
TVQSVAVDGR PGSRPWRRSR EVGTSPEDLQ ELLLPTPLEM HRVTLHKDPV RNDFGFSVSD 960
GLLEKGVYVH TVRIDGPAQH GGLQPFDRLL QVNHVRTRDF DCCLAVPLLA EAGDILELVV 1020
SRNPLAQSRR TPGAPGPSSP QMI 1043
|
FASTA
(Isoform 4) |
>LipidDB-10116-01083|Q9WTW1-4
MRGWRRNLALCLQRLPDEDDGPYSKGGKDTAGTDGALVCRRQSIPEEFRGITMVELIKRE
GSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIRSVNGIRLTRLRHDEIITL
LKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKSRP
LVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALFQVEYDVA
TPDTVANASGPLVVEIAKTPGSALGISLTTGSHRNKPAITIDRIKPASVVDRSGALHAGD
HILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRRPLKPPEAVRIQRSEQLHHW
DPCVPSCHSPRPSHCRAPTWAPGGQDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSP
RTTAGRRRQRRKEHRSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFAT
ETLSSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVV
LEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTG
TLEPGDKLLAIDNIRLDHCPMEYAVQILRQCEDLVKLKIRKDEDNSDEQESSGAVSYTVE
LKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINSVSLKGRPLSE
AIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPPEALKGGLLTTHFSPAVP
SVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEWRSSRLKSSPPPLEPRRTSYTPG
PTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTG
TVQSVAVDGRPGSRPWRRSREVGTSPEDLQELLLPTPLEMHRVTLHKDPVRNDFGFSVSD
GLLEKGVYVHTVRIDGPAQHGGLQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILELVV
SRNPLAQSRRTPGAPGPSSPQMI
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Gene Ontology |
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Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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