| Tag |
Content |
LipidDB ID |
LipidDB-10116-01076 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.48 |
Molecular Weight |
111863.36 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Receptor-type tyrosine-protein phosphatase N2 |
Protein Synonyms/Alias |
R-PTP-N2; 3.1.3.48; PTP NE-6; PTPNE6; Phogrin; |
Gene Name |
Ptprn2 |
Gene Synonyms/Alias |
|
Created Date |
01-NOV-1997 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
627 | Canonical | LASSLAYCLRHNSHY | [1] | S-Palmitoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Implicated in development of nervous system and pancreatic endocrine cells. |
Sequence Annotation |
Topological domain: 28 603 Extracellular.
Transmembrane: 604 624 Helical.
Topological domain: 625 1004 Cytoplasmic.
Domain: 734 994 Tyrosine-protein phosphatase.
Region: 934 940 Substrate binding.
Active site: 934 934 Phosphocysteine intermediate.
Binding site: 902 902 Substrate.
Binding site: 979 979 Substrate.
Functional site: 415 416 Cleavage.
Modified residue: 959 959 N6-acetyllysine.
|
Protein Length |
1004 AA. |
Protein Sequence
(Canonical) |
MGLPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET CVNDGVFGRC 60
QKVPALDTYR YEVSPGALLH LRIILQKLSR TGFTWQDDYT QRVIAQELSN LPKAYLWHEE 120
ASSPARSLQQ NADNEKWFSL ESEVALAKTL RRYLPYLELL SQAPTANAHP RIDHETRPVK 180
GEDSSPENIL TYVAHTSALT YPPATRVKYP DNLLRPLSRL QPDELSPKVD SDIDKQKLIA 240
ALGAYTAQRP PGENDPEPRY LVHSPMRAPR PFAAPALSQR WPLPPGDSKD SLSMGDDTLL 300
RSLLKDLQQQ AEVDRLGSLK LEEQADSIAG AIQSDPVEGS QESHGRGAEG QLREQADAPE 360
EMLQDHRLPE VDDPAAYKEV SRLSFKLGDL LKDHGSPLLP EAPLLEKSSR AEMKKSEQPE 420
EVLSSEEETA GVEHVKSRTY SKDLLERKPN SEPQPWRLED QFQNRAPEVW EDEQNLKLAA 480
QGPPSGGLQL EVQPSEEEQQ GYILTGNNPL SPEKGKQLMD EVAHLLRVPS SFFADVKVLG 540
PAVIFKVSAN IQNMTTADVT KAAVDNKDEL EKATGLTILQ SGIRPKGKLK LLPHPEEQED 600
STKFIVLTFL SIACILAVLL ASSLAYCLRH NSHYKLKEKL SGLGADPSAD ATEAYQELCR 660
QRMAVRPQDH SEGPHTSRIN SVSSQLSDGP MPSPSARSST SSWSEEPAQS NMDISTGHMI 720
LAYMEDHLKN KNRLEKEWEA LCAYQAEPDS SLVAQREENA PKNRSLAVLT YDHSRILLKS 780
ENSHSNSDYI NASPIMDHDP RNPAYIATQG PLPATVADFW QMVWESGCAV IVMLTPLSEN 840
GVRQCHHYWP DEGSNVYHVY EVNLVSEHIW CQDFLVRSFY LKNLQTNETR TVTQFHFLSW 900
YDQGVPSSTR SLLDFRRKVN KCYRGRSCPI IVHCSDGAGR SGTYVLIDMV LNKMAKGAKE 960
IDIAATLEHL RDQRPGMVQT KEQFEFALTA VAEEVNAILK ALPQ 1004
|
FASTA
(Canonical) |
>LipidDB-10116-01076|Q63475
MGLPLPLLLLLLLPPPLPRALPAPASARGRQLPGRLGCLFEDGLCGSLETCVNDGVFGRC
QKVPALDTYRYEVSPGALLHLRIILQKLSRTGFTWQDDYTQRVIAQELSNLPKAYLWHEE
ASSPARSLQQNADNEKWFSLESEVALAKTLRRYLPYLELLSQAPTANAHPRIDHETRPVK
GEDSSPENILTYVAHTSALTYPPATRVKYPDNLLRPLSRLQPDELSPKVDSDIDKQKLIA
ALGAYTAQRPPGENDPEPRYLVHSPMRAPRPFAAPALSQRWPLPPGDSKDSLSMGDDTLL
RSLLKDLQQQAEVDRLGSLKLEEQADSIAGAIQSDPVEGSQESHGRGAEGQLREQADAPE
EMLQDHRLPEVDDPAAYKEVSRLSFKLGDLLKDHGSPLLPEAPLLEKSSRAEMKKSEQPE
EVLSSEEETAGVEHVKSRTYSKDLLERKPNSEPQPWRLEDQFQNRAPEVWEDEQNLKLAA
QGPPSGGLQLEVQPSEEEQQGYILTGNNPLSPEKGKQLMDEVAHLLRVPSSFFADVKVLG
PAVIFKVSANIQNMTTADVTKAAVDNKDELEKATGLTILQSGIRPKGKLKLLPHPEEQED
STKFIVLTFLSIACILAVLLASSLAYCLRHNSHYKLKEKLSGLGADPSADATEAYQELCR
QRMAVRPQDHSEGPHTSRINSVSSQLSDGPMPSPSARSSTSSWSEEPAQSNMDISTGHMI
LAYMEDHLKNKNRLEKEWEALCAYQAEPDSSLVAQREENAPKNRSLAVLTYDHSRILLKS
ENSHSNSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSEN
GVRQCHHYWPDEGSNVYHVYEVNLVSEHIWCQDFLVRSFYLKNLQTNETRTVTQFHFLSW
YDQGVPSSTRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKE
IDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ
|
Gene Ontology |
|
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
PROSITE; PS00383; TYR_PHOSPHATASE_1; PROSITE; PS50056; TYR_PHOSPHATASE_2; PROSITE; PS50055; TYR_PHOSPHATASE_PTP; |
PRINTS |
|