Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01059
Entry Name
UniProt Accession
Theoretical PI
9.35
Molecular Weight
36629.0
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Adenosine receptor A3
Protein Synonyms/Alias
TGPCR1;
Gene Name
Adora3
Gene Synonyms/Alias
Created Date
01-DEC-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
302
Canonical
YFVILRACRLCQTSD
[1]
S-Palmitoylation
305
Canonical
ILRACRLCQTSDSLD
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Ferguson G, Watterson KR, Palmer TM. Subtype-specific regulation of receptorinternalization and recycling by the carboxyl-terminal domains of the human A1and rat A3 adenosine receptors: consequences for agonist-stimulated translocationof arrestin3. Biochemistry. 2002 Dec 17;41(50):14748-61.[PMID:12475223]
Functional Description
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
Sequence Annotation
Topological domain: 1 16 Extracellular.
Transmembrane: 17 39 Helical; Name=1.
Topological domain: 40 50 Cytoplasmic.
Transmembrane: 51 74 Helical; Name=2.
Topological domain: 75 86 Extracellular.
Transmembrane: 87 108 Helical; Name=3.
Topological domain: 109 128 Cytoplasmic.
Transmembrane: 129 150 Helical; Name=4.
Topological domain: 151 179 Extracellular.
Transmembrane: 180 200 Helical; Name=5.
Topological domain: 201 233 Cytoplasmic.
Transmembrane: 234 257 Helical; Name=6.
Topological domain: 258 263 Extracellular.
Transmembrane: 264 286 Helical; Name=7.
Topological domain: 287 320 Cytoplasmic.
Modified residue: 307 307 Phosphothreonine.
Modified residue: 318 318 Phosphothreonine.
Modified residue: 319 319 Phosphothreonine.
Protein Length
320 AA.
Protein Sequence
(Canonical)
MKANNTTTSA LWLQITYITM EAAIGLCAVV GNMLVIWVVK LNRTLRTTTF YFIVSLALAD  60
IAVGVLVIPL AIAVSLEVQM HFYACLFMSC VLLVFTHASI MSLLAIAVDR YLRVKLTVRY  120
RTVTTQRRIW LFLGLCWLVS FLVGLTPMFG WNRKVTLELS QNSSTLSCHF RSVVGLDYMV  180
FFSFITWILI PLVVMCIIYL DIFYIIRNKL SQNLTGFRET RAFYGREFKT AKSLFLVLFL  240
FALCWLPLSI INFVSYFNVK IPEIAMCLGI LLSHANSMMN PIVYACKIKK FKETYFVILR  300
ACRLCQTSDS LDSNLEQTTE                                              320
FASTA
(Canonical)
>LipidDB-10116-01059|P28647
MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALAD
IAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRY
RTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMV
FFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFL
FALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILR
ACRLCQTSDSLDSNLEQTTE
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0042734; C:presynaptic membrane; IDA:RGD
GO:0001609; F:G-protein coupled adenosine receptor activity; IDA:RGD
GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:RGD
GO:0014061; P:regulation of norepinephrine secretion; IMP:RGD
Interpro
InterPro; IPR000466; Adeno_A3_rcpt
InterPro; IPR001634; Adenosn_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00555; ADENOSINEA3R;
PRINTS; PR00424; ADENOSINER;
PRINTS; PR00237; GPCRRHODOPSN;