LipidDB ID

LipidDB-10116-01036

Entry Name

UniProt Accession

Q812E9;

Theoretical PI

5.17

Molecular Weight

31195.51

Genbank Protein ID

BAC56699.1; EDL78956.1; AAH88862.1;

Genbank Nucleotide ID

AB089242; CH473995; BC088862; DV216104;

Protein Name

Neuronal membrane glycoprotein M6-a

Protein Synonyms/Alias

M6a;

Gene Name

Gpm6a

Gene Synonyms/Alias

m6a;

Created Date

13-JUN-2012

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Predicted from GPS-Lipid

Functional Description

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Sequence Annotation

Topological domain: 1 22 Cytoplasmic.
Transmembrane: 23 43 Helical.
Topological domain: 44 84 Extracellular.
Transmembrane: 85 105 Helical.
Topological domain: 106 127 Cytoplasmic.
Transmembrane: 128 148 Helical.
Topological domain: 149 213 Extracellular.
Transmembrane: 214 234 Helical.
Topological domain: 235 278 Cytoplasmic.
Modified residue: 1 1 N-acetylmethionine.

Protein Length

278 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0044295; C:axonal growth cone; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0030175; C:filopodium; IDA:UniProtKB
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0043025; C:neuronal cell body; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005262; F:calcium channel activity; IDA:RGD
GO:0070588; P:calcium ion transmembrane transport; IDA:GOC
GO:0003407; P:neural retina development; ISS:UniProtKB
GO:0001764; P:neuron migration; ISS:UniProtKB
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB
GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB
GO:0048863; P:stem cell differentiation; ISS:UniProtKB
GO:0007416; P:synapse assembly; IDA:UniProtKB

Interpro

InterPro; IPR001614; Myelin_PLP
InterPro; IPR018237; Myelin_PLP_CS

Pfam

Pfam; PF01275; Myelin_PLP;

SMART

SMART; SM00002; PLP;

PROSITE

PROSITE; PS00575; MYELIN_PLP_1;
PROSITE; PS01004; MYELIN_PLP_2;

PRINTS

PRINTS; PR00214; MYELINPLP;