Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-01029
Entry Name
UniProt Accession
Theoretical PI
6.18
Molecular Weight
166878.52
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Leucine-rich repeat-containing protein 7
Protein Synonyms/Alias
Densin-180; Densin; Protein LAP1;
Gene Name
Lrrc7
Gene Synonyms/Alias
Lap1;
Created Date
19-JUL-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
14
Canonical
LIGRLVPCRCFRGEE
[1]
S-Palmitoylation
16
Canonical
GRLVPCRCFRGEEEI
[1]
S-Palmitoylation
481
Canonical
GKVKALSCQAPWDRG
[1]
S-Palmitoylation
503
Canonical
PARLSGDCCTPWARC
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity).
Sequence Annotation
Domain: 1398 1488 PDZ.
Modified residue: 90 90 Phosphoserine.
Modified residue: 197 197 Phosphoserine.
Modified residue: 1392 1392 Phosphoserine.
Protein Length
1490 AA.
Protein Sequence
(Canonical)
MTTKRKLIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE LYLDANQIEE  60
LPKQLFNCQA LRKLSIPDND LSSLPTSIAS LVNLKELDIS KNGVQEFPEN IKCCKCLTII  120
EASVNPISKL PDGFTQLLNL TQLYLNDAFL EFLPANFGRL VKLRILELRE NHLKTLPKSM  180
HKLAQLERLD LGNNEFSELP EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN  240
RIETVDMDIS GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL  300
LEEFDCSCNE LESLPPTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM SLRSNKLEFL  360
PEEIGQMQRL RVLNLSDNRL KNLPFSFTKL KELAALWLSD NQSKALIPLQ TEAHPETKQR  420
VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE EQRQQRMTVA FEFEDKKEDD ESAGKVKALS  480
CQAPWDRGQR GITLQPARLS GDCCTPWARC DQQIQDMPVP QSDPQLAWGC ISGLQQERSM  540
CAPLPVAAQS TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENAN  600
PTANTEQTVK EKFEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP LYPPKLVLLG  660
KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSASS NTRVKVGSLQ PTTKDAVHNS  720
LWGNRIAPPF PQPLDAKPLL TQREAVPPGN LPQRPDRLPM SDAFPDNWTD GSHYDNTGFV  780
SEEATGENAN NNPLLSSKAR SVPAHGRRPL IRQERIVGVP LELEQSTHRH TPETEVPPSN  840
PWQNWTRTPS PFEDRTAFPS KLETTPTTSP LPERKDHMKE PTETPGPFSP GVPWEYHDPT  900
PNRSLGNVFS QIHCRPDSSK GVIAISKSTE RLSPLMKDIK SNKFKKSQSI DEIDVGTYKV  960
YNIPLENYAS GSDHLGSHER PDKFLGPEHG MSSMSRSQSV PMLDDEMLMY GSSKGPPQQK  1020
ASMTKKVYQF DQSFNPQGAV EVKAEKRIPP PFAHNSEYVQ QPGKNIAKDL VSPRAYRGYP  1080
PMEQMFSFSQ PSVNEDAMVN AQFASQGPRA GFLRRADSLA SSTEMAMFRR VSEPHELPPG  1140
DRYGRAAYRG GLEGQSSVSM TDPQFLKRNG RYEDEHPSYQ EVKAQAGSFP AKNLTQRRPL  1200
SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKTSDNSDI KTRPTPVKGE  1260
ESCGKMPADW RQQLLRHIEA RRLDRTPSQQ SNILDNGQED VSPSGQWNPY PLGRRDVPPD  1320
TITKKAGSHI QTLMGSQSLQ HRSREQQPYE GNINKVTIQQ FQSPLPIQIP SSQATRGPQP  1380
GRCLIQTKGQ RSMDGYPEQF CVRIEKNPGL GFSISGGISG QGNPFKPSDK GIFVTRVQPD  1440
GPASNLLQPG DKILQANGHS FVHMEHEKAV LLLKSFQNTV DLVIQRELTV             1490
FASTA
(Canonical)
>LipidDB-10116-01029|P70587
MTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE
LPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTII
EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM
HKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN
RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL
LEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL
PEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR
VLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALS
CQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSM
CAPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENAN
PTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLG
KDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRVKVGSLQPTTKDAVHNS
LWGNRIAPPFPQPLDAKPLLTQREAVPPGNLPQRPDRLPMSDAFPDNWTDGSHYDNTGFV
SEEATGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSN
PWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPT
PNRSLGNVFSQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKV
YNIPLENYASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQK
ASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPGKNIAKDLVSPRAYRGYP
PMEQMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPG
DRYGRAAYRGGLEGQSSVSMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRPL
SARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPVKGE
ESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPD
TITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQP
GRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPD
GPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
Gene Ontology
GO:0043194; C:axon initial segment; IDA:RGD
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0005737; C:cytoplasm; IDA:RGD
GO:0043197; C:dendritic spine; IDA:RGD
GO:0030175; C:filopodium; IDA:RGD
GO:0043005; C:neuron projection; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0014069; C:postsynaptic density; IDA:RGD
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW
GO:0045202; C:synapse; IDA:RGD
GO:0008022; F:protein C-terminus binding; IDA:RGD
GO:0010976; P:positive regulation of neuron projection development; IDA:RGD
GO:0014070; P:response to organic cyclic compound; IEP:RGD
Interpro
InterPro; IPR001611; Leu-rich_rpt
InterPro; IPR025875; Leu-rich_rpt_4
InterPro; IPR001478; PDZ
Pfam
Pfam; PF00560; LRR_1;
Pfam; PF12799; LRR_4;
Pfam; PF13855; LRR_8;
Pfam; PF00595; PDZ;
SMART
SMART; SM00228; PDZ;
PROSITE
PROSITE; PS51450; LRR;
PROSITE; PS50106; PDZ;
PRINTS