| Tag |
Content |
LipidDB ID |
LipidDB-10116-00956 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.1 |
Molecular Weight |
37440.57 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 |
Protein Synonyms/Alias |
1.-.-.-; 1.14.-.-; Degenerative spermatocyte homolog 2; |
Gene Name |
Degs2 |
Gene Synonyms/Alias |
Des2; |
Created Date |
04-DEC-2007 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGNSAARSD | [1] | N-Myristoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Beauchamp E, Goenaga D, Le Bloc'h J, Catheline D, Legrand P, Rioux V. Myristicacid increases the activity of dihydroceramide Delta4-desaturase 1 through itsN-terminal myristoylation. Biochimie. 2007 Dec;89(12):1553-61. Epub 2007 Jul 15.[ PMID:17716801]
|
Functional Description |
Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. |
Sequence Annotation |
Transmembrane: 41 61 Helical.
Transmembrane: 68 88 Helical.
Transmembrane: 200 220 Helical.
Region: 95 99 Required for C4-hydroxylase activity.
|
Protein Length |
323 AA. |
Protein Sequence
(Canonical) |
MGNSAARSDF EWVYSDQPHT QRRKEMLAKY PSIKALMRPD PNIKWTVLGM VLVQVLACWL 60
VRGLSWRWLL FWAYAFGGCI NHSLTLAIHD ISHNTAFGTR CASRNRWFAV FANLPIGLPY 120
ATSFKKYHVD HHRYLGGDGL DVDIPTDFEG WFFCTPARKL LWLVLQPFFY SLRPLYVNPK 180
AVTRMEILNA LVQLAFNVTI FALWGIKAIV YLLASSLLGL GLHPISGHFV AEHYMFLKGH 240
ETYSYYGPLN WITFNVGYHV EHHDFPSIPG CYLPLVRMIA PEYYDHLPQH HSWVKVLWDF 300
VFEDSLGPYS RVKRKCKLAK DQL 323
|
FASTA
(Canonical) |
>LipidDB-10116-00956|Q564G3
MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPSIKALMRPDPNIKWTVLGMVLVQVLACWL
VRGLSWRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTRCASRNRWFAVFANLPIGLPY
ATSFKKYHVDHHRYLGGDGLDVDIPTDFEGWFFCTPARKLLWLVLQPFFYSLRPLYVNPK
AVTRMEILNALVQLAFNVTIFALWGIKAIVYLLASSLLGLGLHPISGHFVAEHYMFLKGH
ETYSYYGPLNWITFNVGYHVEHHDFPSIPGCYLPLVRMIAPEYYDHLPQHHSWVKVLWDF
VFEDSLGPYSRVKRKCKLAKDQL
|
Gene Ontology |
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0042284; F:sphingolipid delta-4 desaturase activity; IEA:Ensembl GO:0000170; F:sphingosine hydroxylase activity; IEA:Ensembl GO:0046513; P:ceramide biosynthetic process; IEA:Ensembl GO:0006667; P:sphinganine metabolic process; IEA:Ensembl |
Interpro |
InterPro; IPR005804; Fatty_acid_desaturase-1 InterPro; IPR011388; Sphingolipid_d4-desaturase InterPro; IPR013866; Sphingolipid_d4-desaturase_N |
Pfam |
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SMART |
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PROSITE |
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PRINTS |
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