Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00831
Entry Name
UniProt Accession
Theoretical PI
9.35
Molecular Weight
47655.17
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Vasopressin V1a receptor
Protein Synonyms/Alias
V1aR; AVPR V1a; Antidiuretic hormone receptor 1a; Vascular/hepatic-type arginine vasopressin receptor;
Gene Name
Avpr1a
Gene Synonyms/Alias
Created Date
01-APR-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
371
Canonical
DCVQSFPCCHSMAQK
[1]
S-Palmitoylation
372
Canonical
CVQSFPCCHSMAQKF
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Hawtin SR, Tobin AB, Patel S, Wheatley M. Palmitoylation of the vasopressinV1a receptor reveals different conformational requirements for signaling,agonist-induced receptor phosphorylation, and sequestration. J Biol Chem. 2001Oct 12;276(41):38139-46. Epub 2001 Jul 20.[PMID:11466323]
Functional Description
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation.
Sequence Annotation
Topological domain: 1 52 Extracellular.
Transmembrane: 53 76 Helical; Name=1.
Topological domain: 77 88 Cytoplasmic.
Transmembrane: 89 110 Helical; Name=2.
Topological domain: 111 125 Extracellular.
Transmembrane: 126 147 Helical; Name=3.
Topological domain: 148 168 Cytoplasmic.
Transmembrane: 169 190 Helical; Name=4.
Topological domain: 191 220 Extracellular.
Transmembrane: 221 241 Helical; Name=5.
Topological domain: 242 299 Cytoplasmic.
Transmembrane: 300 319 Helical; Name=6.
Topological domain: 320 337 Extracellular.
Transmembrane: 338 357 Helical; Name=7.
Topological domain: 358 424 Cytoplasmic.
Modified residue: 410 410 Phosphoserine.
Protein Length
424 AA.
Protein Sequence
(Canonical)
MSFPRGSQDR SVGNSSPWWP LTTEGSNGSQ EAARLGEGDS PLGDVRNEEL AKLEIAVLAV  60
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP  120
DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IATSWVLSFI  180
LSTPQYFIFS VIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVAP VVVLGTCYGF  240
ICYHIWRNIR GKTASSRHSK GDKGSGEAVG PFHKGLLVTP CVSSVKSISR AKIRTVKMTF  300
VIVSAYILCW APFFIVQMWS VWDENFIWTD SENPSITITA LLASLNSCCN PWIYMFFSGH  360
LLQDCVQSFP CCHSMAQKFA KDDSDSMSRR QTSYSNNRSP TNSTGMWKDS PKSSKSIRFI  420
PVST                                                               424
FASTA
(Canonical)
>LipidDB-10116-00831|P30560
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFI
LSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGF
ICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTF
VIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGH
LLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFI
PVST
Gene Ontology
GO:0031410; C:cytoplasmic vesicle; IDA:RGD
GO:0016021; C:integral component of membrane; NAS:UniProtKB
GO:0005886; C:plasma membrane; IDA:RGD
GO:0017046; F:peptide hormone binding; IMP:RGD
GO:0031894; F:V1A vasopressin receptor binding; IDA:UniProtKB
GO:0005000; F:vasopressin receptor activity; IDA:RGD
GO:0019722; P:calcium-mediated signaling; IMP:RGD
GO:0042631; P:cellular response to water deprivation; IEP:RGD
GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:UniProtKB
GO:0007625; P:grooming behavior; IMP:RGD
GO:0002125; P:maternal aggressive behavior; IMP:RGD
GO:0042711; P:maternal behavior; IMP:RGD
GO:0014902; P:myotube differentiation; IEP:RGD
GO:0007621; P:negative regulation of female receptivity; IMP:RGD
GO:0051970; P:negative regulation of transmission of nerve impulse; IMP:RGD
GO:0043084; P:penile erection; IMP:RGD
GO:0045777; P:positive regulation of blood pressure; IMP:RGD
GO:0030307; P:positive regulation of cell growth; IMP:RGD
GO:0008284; P:positive regulation of cell proliferation; IMP:RGD
GO:0032849; P:positive regulation of cellular pH reduction; IMP:RGD
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD
GO:0014049; P:positive regulation of glutamate secretion; IMP:RGD
GO:0045819; P:positive regulation of glycogen catabolic process; NAS:UniProtKB
GO:0010460; P:positive regulation of heart rate; IMP:RGD
GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IMP:RGD
GO:0035815; P:positive regulation of renal sodium excretion; IMP:RGD
GO:0003084; P:positive regulation of systemic arterial blood pressure; IMP:RGD
GO:0035810; P:positive regulation of urine volume; NAS:UniProtKB
GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD
GO:0051459; P:regulation of corticotropin secretion; NAS:UniProtKB
GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; TAS:RGD
GO:0051412; P:response to corticosterone; IEP:RGD
GO:0010035; P:response to inorganic substance; IMP:RGD
GO:0010033; P:response to organic substance; IMP:RGD
GO:0035176; P:social behavior; IDA:UniProtKB
GO:0042713; P:sperm ejaculation; IMP:RGD
GO:0021537; P:telencephalon development; IEP:RGD
Interpro
InterPro; IPR015076; DUF1856
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR001817; Vasoprsn_rcpt
InterPro; IPR001224; Vprs_V1A_rcpt
Pfam
Pfam; PF00001; 7tm_1;
Pfam; PF08983; DUF1856;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR00896; VASOPRESSINR;
PRINTS; PR00752; VASOPRSNV1AR;