Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00811
Entry Name
UniProt Accession
Theoretical PI
9.17
Molecular Weight
60282.35
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
NMDA receptor synaptonuclear signaling and neuronal migration factor
Protein Synonyms/Alias
Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Jacob protein; Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor;
Gene Name
Nsmf
Gene Synonyms/Alias
Jac; Nelf;
Created Date
19-JUL-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGAAASRRR
[1]
N-Myristoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, König I, Landwehr M, KreutzM, Smalla KH, Richter K, Landgraf P, Reissner C, Boeckers TM, Zuschratter W,Spilker C, Seidenbecher CI, Garner CC, Gundelfinger ED, Kreutz MR.Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PLoS Biol. 2008 Feb;6(2):e34. doi: 10.1371/journal.pbio.0060034. Erratumin: PLoS Biol. 2009 Jan;7(1):e1000022.[PMID:18303947]
Functional Description
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
Sequence Annotation
Region: 2 235 Necessary and sufficient to elicitdendritic processes and synapticcontacts.
Motif: 247 252 Nuclear localization signal.
Protein Length
532 AA.
Protein Sequence
(Canonical)
MGAAASRRRA LRSEAMSSVA AKVRAARAFG EYLSQSHPEN RNGADHLLAD AYSGHEGSPE  60
MQPAPHNKRR LSLVSNGRYE GSISDEAVSG KTATEGPQPR VYTISREPAL LPGSEAEAIE  120
LAVVKGRRQR ERHPHHHSQP LRASPGSSRE DISRPCQSWA GSRQGSKECP GCAKLVPGPS  180
PRAFGLEQPP LPEASGRHKK LERMYSVDGV SDDVPIRTWF PKENPFSFQT ATTTMQAISV  240
FRGYAERKRR KRENDSASVI QRNFRKHLRM VGSRRVKAQT FAERRERSFS RSWSDPTPMK  300
ADTSHDSRDS SDLQSSHCTL DEACEDLDWD TEKGLEATAC DTEGFLPPKV MLISSKVPKA  360
EYIPTIIRRD DPSIIPILYD HEHATFEDIL EEIEKKLNIY HKGAKIWKML IFCQGGPGHL  420
YLLKNKVATF AKVEKEEDMI HFWKRLSRLM SKVNPEPNVI HIMGCYILGN PNGEKLFQNL  480
RTLMTPYKVT FESPLELSAQ GKQMIETYFD FRLYRLWKSR QHSKLLDFDD VL          532
FASTA
(Canonical)
>LipidDB-10116-00811|Q9EPI6
MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHEGSPE
MQPAPHNKRRLSLVSNGRYEGSISDEAVSGKTATEGPQPRVYTISREPALLPGSEAEAIE
LAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWAGSRQGSKECPGCAKLVPGPS
PRAFGLEQPPLPEASGRHKKLERMYSVDGVSDDVPIRTWFPKENPFSFQTATTTMQAISV
FRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMK
ADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKGLEATACDTEGFLPPKVMLISSKVPKA
EYIPTIIRRDDPSIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHL
YLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNL
RTLMTPYKVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL
Gene Ontology
GO:0097440; C:apical dendrite; IDA:UniProtKB
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0030863; C:cortical cytoskeleton; IDA:UniProtKB
GO:0005737; C:cytoplasm; ISS:UniProtKB
GO:0030425; C:dendrite; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0005635; C:nuclear envelope; IDA:UniProtKB
GO:0005719; C:nuclear euchromatin; IDA:UniProtKB
GO:0016363; C:nuclear matrix; IDA:UniProtKB
GO:0031965; C:nuclear membrane; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0043204; C:perikaryon; IDA:UniProtKB
GO:0014069; C:postsynaptic density; IDA:UniProtKB
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW
GO:0045202; C:synapse; IDA:UniProtKB
GO:0048306; F:calcium-dependent protein binding; IDA:UniProtKB
GO:0071230; P:cellular response to amino acid stimulus; IDA:UniProtKB
GO:0071257; P:cellular response to electrical stimulus; IDA:UniProtKB
GO:0071371; P:cellular response to gonadotropin stimulus; ISS:UniProtKB
GO:2001224; P:positive regulation of neuron migration; ISS:UniProtKB
GO:0035307; P:positive regulation of protein dephosphorylation; IMP:UniProtKB
GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB
GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB
GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:UniProtKB
Interpro
Pfam
SMART
PROSITE
PRINTS