Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00810
Entry Name
UniProt Accession
Theoretical PI
5.12
Molecular Weight
28755.69
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Kv channel-interacting protein 4
Protein Synonyms/Alias
KChIP4; A-type potassium channel modulatory protein 4; Potassium channel-interacting protein 4;
Gene Name
Kcnip4
Gene Synonyms/Alias
Kchip4;
Created Date
16-AUG-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
43
Canonical
RLMKLLPCSAAKTSS
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Takimoto K, Yang EK, Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem.2002 Jul 26;277(30):26904-11. Epub 2002 May 10.[PMID:12006572]
Functional Description
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND3/Kv4.3 and KCND2/Kv4.2 currents (By similarity).
Sequence Annotation
Domain: 61 117 EF-hand 1; degenerate.
Domain: 120 155 EF-hand 2.
Domain: 156 191 EF-hand 3.
Domain: 204 239 EF-hand 4.
Region: 2 44 KIS.
Region: 237 250 Interaction with KCND2.
Protein Length
250 AA.
Protein Sequence
(Canonical)
MNVRRVESIS AQLEEASSTG GFLYAQNNTK RSIKERLMKL LPCSAAKTSS PAIQNSVEDE  60
LEMATVRHRP EALELLEAQS KFTKKELQIL YRGFKNECPS GVVNEETFKE IYSQFFPQGD  120
STTYAHFLFN AFDTDHNGAV SFEDFIKGLS ILLRGTVQEK LNWAFNLYDI NKDGYITKEE  180
MLDIMKAIYD MMGKCTYPVL KEDAPRQHVE TFFQKMDKNK DGVVTIDEFI ESCQKDENIM  240
RSMQLFENVI                                                         250
FASTA
(Canonical)
>LipidDB-10116-00810|Q99MG9
MNVRRVESISAQLEEASSTGGFLYAQNNTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDE
LEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGD
STTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEE
MLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIM
RSMQLFENVI
Gene Ontology
GO:0030425; C:dendrite; IDA:RGD
GO:0016020; C:membrane; IDA:RGD
GO:0043025; C:neuronal cell body; IDA:RGD
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin
Pfam
Pfam; PF13499; EF-hand_7;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;
PRINTS