Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00801
Entry Name
UniProt Accession
Theoretical PI
5.46
Molecular Weight
29470.57
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Calsenilin
Protein Synonyms/Alias
A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3;
Gene Name
Kcnip3
Gene Synonyms/Alias
Csen; Dream; Kchip3;
Created Date
27-APR-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
45
Canonical
TRQALMRCCLIKWIL
[1]
S-Palmitoylation
46
Canonical
RQALMRCCLIKWILS
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Takimoto K, Yang EK, Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem.2002 Jul 26;277(30):26904-11. Epub 2002 May 10.[PMID:12006572]
Functional Description
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Sequence Annotation
Domain: 67 123 EF-hand 1; degenerate.
Domain: 126 161 EF-hand 2.
Domain: 162 197 EF-hand 3.
Domain: 210 245 EF-hand 4.
Region: 243 256 Interaction with KCND2.
Modified residue: 63 63 Phosphoserine.
Protein Length
256 AA.
Protein Sequence
(Canonical)
MQRTKEAMKA SDGSLLGDPG RIPLSKREGI KWQRPRFTRQ ALMRCCLIKW ILSSAAPQGS  60
DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYSQ  120
FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG  180
YITKEEMLAI MKSIYDMMGR HTYPILREDA PLEHVERFFQ KMDRNQDGVV TIDEFLETCQ  240
KDENIMSSMQ LFENVI                                                  256
FASTA
(Canonical)
>LipidDB-10116-00801|Q9JM47
MQRTKEAMKASDGSLLGDPGRIPLSKREGIKWQRPRFTRQALMRCCLIKWILSSAAPQGS
DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQ
FFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDG
YITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQ
KDENIMSSMQLFENVI
Gene Ontology
GO:0030424; C:axon; IDA:RGD
GO:0043679; C:axon terminus; IDA:RGD
GO:0005829; C:cytosol; IEA:Ensembl
GO:0030425; C:dendrite; IDA:RGD
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IDA:RGD
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0032993; C:protein-DNA complex; IDA:RGD
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0044325; F:ion channel binding; IPI:RGD
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW
GO:0015459; F:potassium channel regulator activity; IDA:RGD
GO:0043565; F:sequence-specific DNA binding; IDA:RGD
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW
GO:0048266; P:behavioral response to pain; IEA:Ensembl
GO:0006886; P:intracellular protein transport; IMP:RGD
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl
GO:0019233; P:sensory perception of pain; IEA:Ensembl
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin
Pfam
Pfam; PF13499; EF-hand_7;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;
PRINTS