LipidDB-10116-00780

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10116-00780

Entry Name

KCIP2_RAT

UniProt Accession

Q9JM59; Q9JI21; Q9JI22; Q9JI23; Q9JM60;

Theoretical PI

4.93

Molecular Weight

30932.76

Genbank Protein ID

BAA92743.1; BAA92744.1; AAF81755.1; AAF81756.1; AAF81757.1; AAH85905.1;

Genbank Nucleotide ID

AB040031; AB040032; AF269283; AF269284; AF269285; BC085905;

Protein Name

Kv channel-interacting protein 2

Protein Synonyms/Alias

KChIP2; A-type potassium channel modulatory protein 2; Potassium channel-interacting protein 2;

Gene Name

Kcnip2

Gene Synonyms/Alias

Kchip2;

Created Date

16-AUG-2005

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
45	Canonical	RFLKLLPCCGPQALP	[1]	S-Palmitoylation
46	Canonical	FLKLLPCCGPQALPS	[1]	S-Palmitoylation

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Takimoto K, Yang EK, Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem.2002 Jul 26;277(30):26904-11. Epub 2002 May 10.[PMID:12006572]

Functional Description

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface.

Sequence Annotation

Domain: 81 137 EF-hand 1; degenerate.
Domain: 140 175 EF-hand 2.
Domain: 176 211 EF-hand 3.
Domain: 224 259 EF-hand 4.
Region: 257 270 Interaction with KCND2.

Protein Length

270 AA.

Protein Sequence
(Canonical)

MRGQGRKESL SESRDLDGSY DQLTGHPPGP SKKALKQRFL KLLPCCGPQA LPSVSETLAA  60
PASLRPHRPR PLDPDSVEDE FELSTVCHRP EGLEQLQEQT KFTRRELQVL YRGFKNECPS  120
GIVNEENFKQ IYSQFFPQGD SSNYATFLFN AFDTNHDGSV SFEDFVAGLS VILRGTIDDR  180
LSWAFNLYDL NKDGCITKEE MLDIMKSIYD MMGKYTYPAL REEAPREHVE SFFQKMDRNK  240
DGVVTIEEFI ESCQQDENIM RSMQLFDNVI                                   270

FASTA
(Canonical)

>LipidDB-10116-00780|Q9JM59
MRGQGRKESLSESRDLDGSYDQLTGHPPGPSKKALKQRFLKLLPCCGPQALPSVSETLAA
PASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKFTRRELQVLYRGFKNECPS
GIVNEENFKQIYSQFFPQGDSSNYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTIDDR
LSWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNK
DGVVTIEEFIESCQQDENIMRSMQLFDNVI

Gene Ontology

GO:0030425; C:dendrite; IDA:RGD
GO:0008076; C:voltage-gated potassium channel complex; IDA:RGD
GO:0005509; F:calcium ion binding; IDA:RGD
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW
GO:0015459; F:potassium channel regulator activity; IDA:RGD
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW
GO:0045163; P:clustering of voltage-gated potassium channels; IDA:RGD
GO:0051291; P:protein heterooligomerization; IDA:RGD

Interpro

InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR029532; KCNIP2
InterPro; IPR028846; Recoverin

Pfam

Pfam; PF13499; EF-hand_7;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS