LipidDB ID

LipidDB-10116-00748

Entry Name

UniProt Accession

P22909;

Theoretical PI

9.7

Molecular Weight

48939.6

Genbank Protein ID

AAA42034.1; AAC24959.1;

Genbank Nucleotide ID

M62372; U79031;

Protein Name

Alpha-2A adrenergic receptor

Protein Synonyms/Alias

Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR; Alpha-2D adrenergic receptor; CA2-47;

Gene Name

Adra2a

Gene Synonyms/Alias

Created Date

01-AUG-1991

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Barclay E, O'Reilly M, Milligan G. Activation of analpha2A-adrenoceptor-Galphao1 fusion protein dynamically regulates thepalmitoylation status of the G protein but not of the receptor. Biochem J. 2005Jan 1;385(Pt 1):197-206.[PMID:15362975]

Functional Description

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.

Sequence Annotation

Topological domain: 1 33 Extracellular.
Transmembrane: 34 59 Helical; Name=1.
Topological domain: 60 70 Cytoplasmic.
Transmembrane: 71 96 Helical; Name=2.
Topological domain: 97 106 Extracellular.
Transmembrane: 107 129 Helical; Name=3.
Topological domain: 130 149 Cytoplasmic.
Transmembrane: 150 173 Helical; Name=4.
Topological domain: 174 192 Extracellular.
Transmembrane: 193 217 Helical; Name=5.
Topological domain: 218 374 Cytoplasmic.
Transmembrane: 375 399 Helical; Name=6.
Topological domain: 400 409 Extracellular.
Transmembrane: 410 430 Helical; Name=7.
Topological domain: 431 450 Cytoplasmic.
Functional site: 113 113 Implicated in ligand binding.
Functional site: 200 200 Implicated in catechol agonist binding.
Functional site: 204 204 Implicated in catechol agonist binding.

Protein Length

450 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:RGD
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:RGD
GO:0043235; C:receptor complex; IEA:Ensembl
GO:0045202; C:synapse; IDA:RGD
GO:0004938; F:alpha2-adrenergic receptor activity; IDA:RGD
GO:0051379; F:epinephrine binding; IEA:Ensembl
GO:0051380; F:norepinephrine binding; IEA:Ensembl
GO:0071883; P:activation of MAPK activity by adrenergic receptor signaling pathway; IEA:Ensembl
GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl
GO:0002526; P:acute inflammatory response; IMP:RGD
GO:0071881; P:adenylate cyclase-inhibiting adrenergic receptor signaling pathway; IEA:Ensembl
GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl
GO:0006260; P:DNA replication; IMP:RGD
GO:0035625; P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; IEA:Ensembl
GO:0042596; P:fear response; IEA:Ensembl
GO:0007565; P:female pregnancy; IMP:RGD
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:BHF-UCL
GO:0042593; P:glucose homeostasis; IMP:BHF-UCL
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IMP:BHF-UCL
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:BHF-UCL
GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl
GO:0070473; P:negative regulation of uterine smooth muscle contraction; IMP:RGD
GO:0071882; P:phospholipase C-activating adrenergic receptor signaling pathway; IEA:Ensembl
GO:0030168; P:platelet activation; IEA:InterPro
GO:0030335; P:positive regulation of cell migration; IEA:Ensembl
GO:0001819; P:positive regulation of cytokine production; IEA:Ensembl
GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl
GO:0045909; P:positive regulation of vasodilation; IMP:RGD
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl
GO:0019229; P:regulation of vasoconstriction; IEA:InterPro
GO:0007165; P:signal transduction; IEP:RGD
GO:0050955; P:thermoception; IDA:RGD

Interpro

InterPro; IPR002233; ADR_fam
InterPro; IPR001946; ADRA2A_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR01103; ADRENERGICR;
PRINTS; PR00558; ADRENRGCA2AR;
PRINTS; PR00237; GPCRRHODOPSN;