Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00705
Entry Name
UniProt Accession
Theoretical PI
8.51
Molecular Weight
59697.5
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Excitatory amino acid transporter 1
Protein Synonyms/Alias
Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3;
Gene Name
Slc1a3
Gene Synonyms/Alias
Eaat1;
Created Date
01-MAR-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
186
Canonical
PPNLVEACFKQFKTS
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Sequence Annotation
Topological domain: 1 47 Cytoplasmic.
Transmembrane: 48 68 Helical.
Transmembrane: 91 111 Helical.
Transmembrane: 123 145 Helical.
Topological domain: 146 237 Extracellular.
Transmembrane: 238 260 Helical.
Transmembrane: 281 302 Helical.
Transmembrane: 319 340 Helical.
Protein Length
543 AA.
Protein Sequence
(Canonical)
MTKSNGEEPR MGSRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF VLLTVSAVIV  60
GTILGFALRP YKMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG  120
MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMYREGK IVQVTAADAF LDLIRNMFPP  180
NLVEACFKQF KTSYEKRSFK VPIQANETLL GAVINNVSEA METLTRIREE MVPVPGSVNG  240
VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK  300
ILEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL  360
GTSSSSATLP ITFKCLEENN GVDKRITRFV LPVGATINMD GTALYEALAA IFIAQVNNFD  420
LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT  480
TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN EPEKPVADSE  540
TKM                                                                543
FASTA
(Canonical)
>LipidDB-10116-00705|P24942
MTKSNGEEPRMGSRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVSAVIV
GTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPP
NLVEACFKQFKTSYEKRSFKVPIQANETLLGAVINNVSEAMETLTRIREEMVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGK
ILEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFD
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNEPEKPVADSE
TKM
Gene Ontology
GO:0016323; C:basolateral plasma membrane; IDA:RGD
GO:0043197; C:dendritic spine; IDA:RGD
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005743; C:mitochondrial inner membrane; IDA:RGD
GO:0043005; C:neuron projection; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0045202; C:synapse; IDA:RGD
GO:0005314; F:high-affinity glutamate transmembrane transporter activity; IMP:RGD
GO:0005313; F:L-glutamate transmembrane transporter activity; IDA:RGD
GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro
GO:0015813; P:L-glutamate transport; IDA:MGI
GO:0043490; P:malate-aspartate shuttle; IDA:RGD
GO:0006836; P:neurotransmitter transport; TAS:RGD
GO:0010035; P:response to inorganic substance; IDA:MGI
Interpro
InterPro; IPR001991; Na-dicarboxylate_symporter
InterPro; IPR018107; Na-dicarboxylate_symporter_CS
Pfam
Pfam; PF00375; SDF;
SMART
PROSITE
PROSITE; PS00713; NA_DICARBOXYL_SYMP_1;
PROSITE; PS00714; NA_DICARBOXYL_SYMP_2;
PRINTS
PRINTS; PR00173; EDTRNSPORT;