Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00703
Entry Name
UniProt Accession
Theoretical PI
9.18
Molecular Weight
30196.87
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
GTP-binding protein Rhes
Protein Synonyms/Alias
Ras homolog enriched in striatum; SE6C;
Gene Name
Rasd2
Gene Synonyms/Alias
Created Date
31-AUG-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
263
Canonical
QARERDKCSIQ****
[1]
S-Farnesylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P,Bernal J. The small GTP-binding protein, Rhes, regulates signal transduction fromG protein-coupled receptors. Oncogene. 2004 Jan 15;23(2):559-68.[PMID:14724584]
Functional Description
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Sequence Annotation
Nucleotide-binding: 26 33 GTP.
Nucleotide-binding: 73 77 GTP.
Nucleotide-binding: 140 143 GTP.
Region: 189 235 Interaction with GNB1, GNB2 and GNB3.
Motif: 48 56 Effector region.
Modified residue: 263 263 Cysteine methyl ester.
Protein Length
266 AA.
Protein Sequence
(Canonical)
MMKTLSSGNC TLNVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP TIEDFHRKVY  60
NIHGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL DSRESFDEVK RLQKQILEVK  120
SCLKNKTKEA AELPMVICGN KNDHSELCRQ VPAMEAELLV SGDENCAYFE VSAKKNTNVN  180
EMFYVLFSMA KLPHEMSPAL HHKISVQYGD AFHPRPFCMR RTKVAGAYGM VSPFARRPSV  240
NSDLKYIKAK VLREGQARER DKCSIQ                                       266
FASTA
(Canonical)
>LipidDB-10116-00703|P63033
MMKTLSSGNCTLNVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY
NIHGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDSRESFDEVKRLQKQILEVK
SCLKNKTKEAAELPMVICGNKNDHSELCRQVPAMEAELLVSGDENCAYFEVSAKKNTNVN
EMFYVLFSMAKLPHEMSPALHHKISVQYGDAFHPRPFCMRRTKVAGAYGMVSPFARRPSV
NSDLKYIKAKVLREGQARERDKCSIQ
Gene Ontology
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:MGI
GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:UniProtKB
GO:0031624; F:ubiquitin conjugating enzyme binding; IPI:UniProtKB
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0007626; P:locomotory behavior; ISS:UniProtKB
GO:0031397; P:negative regulation of protein ubiquitination; IDA:UniProtKB
GO:0051897; P:positive regulation of protein kinase B signaling; IDA:UniProtKB
GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB
GO:0043949; P:regulation of cAMP-mediated signaling; IDA:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00173; RAS;
PROSITE
PROSITE; PS51421; RAS;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;