LipidDB ID

LipidDB-10116-00651

Entry Name

UniProt Accession

P62168; P36610; Q9UK26;

Theoretical PI

4.71

Molecular Weight

21878.72

Genbank Protein ID

AAA88510.1; CAA57678.1;

Genbank Nucleotide ID

L27421; X82188;

Protein Name

Neuronal calcium sensor 1

Protein Synonyms/Alias

NCS-1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein;

Gene Name

Ncs1

Gene Synonyms/Alias

Flup; Freq;

Created Date

21-JUN-2004

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] McFerran BW, Weiss JL, Burgoyne RD. Neuronal Ca(2+) sensor 1. Characterizationof the myristoylated protein, its cellular effects in permeabilized adrenalchromaffin cells, Ca(2+)-independent membrane association, and interaction withbinding proteins, suggesting a role in rapid Ca(2+) signal transduction. J BiolChem. 1999 Oct 15;274(42):30258-65.[PMID:10514519]

Functional Description

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long- term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.

Sequence Annotation

Domain: 24 59 EF-hand 1.
Domain: 60 95 EF-hand 2.
Domain: 96 131 EF-hand 3.
Domain: 144 179 EF-hand 4.
Region: 36 47 Ancestral calcium site 1.
Region: 174 190 Interaction with IL1RAPL1.

Protein Length

190 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0031410; C:cytoplasmic vesicle; IDA:RGD
GO:0005829; C:cytosol; IDA:RGD
GO:0030425; C:dendrite; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IDA:RGD
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW
GO:0005509; F:calcium ion binding; IDA:RGD
GO:0008427; F:calcium-dependent protein kinase inhibitor activity; TAS:UniProtKB
GO:0000287; F:magnesium ion binding; IDA:RGD
GO:0019901; F:protein kinase binding; IPI:RGD
GO:0005245; F:voltage-gated calcium channel activity; IMP:UniProtKB
GO:0070588; P:calcium ion transmembrane transport; IMP:GOC
GO:0006469; P:negative regulation of protein kinase activity; TAS:GOC
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:RGD
GO:0045921; P:positive regulation of exocytosis; IDA:RGD
GO:0010975; P:regulation of neuron projection development; IMP:UniProtKB

Interpro

InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin

Pfam

Pfam; PF00036; EF-hand_1;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS