LipidDB ID

LipidDB-10116-00620

Entry Name

UniProt Accession

P31016; P97631;

Theoretical PI

5.58

Molecular Weight

80465.35

Genbank Protein ID

AAA41971.1; CAA47103.1; AAB38270.1;

Genbank Nucleotide ID

M96853; X66474; U77090;

Protein Name

Disks large homolog 4

Protein Synonyms/Alias

Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90;

Gene Name

Dlg4

Gene Synonyms/Alias

Dlgh4; Psd95;

Created Date

01-JUL-1993

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C,Bredt DS. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting,postsynaptic targeting, and ion channel clustering. J Cell Biol. 2000 Jan10;148(1):159-72.[PMID:10629226]

Functional Description

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

Sequence Annotation

Domain: 65 151 PDZ 1.
Domain: 160 246 PDZ 2.
Domain: 313 393 PDZ 3.
Domain: 428 498 SH3.
Domain: 534 709 Guanylate kinase-like.
Modified residue: 142 142 Phosphoserine.
Modified residue: 240 240 Phosphotyrosine.
Modified residue: 580 580 Phosphotyrosine.
Modified residue: 715 715 Phosphotyrosine.

Protein Length

724 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:BHF-UCL
GO:0030054; C:cell junction; ISS:BHF-UCL
GO:0044300; C:cerebellar mossy fiber; IEA:Ensembl
GO:0030863; C:cortical cytoskeleton; IEA:Ensembl
GO:0005737; C:cytoplasm; ISS:BHF-UCL
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL
GO:0043197; C:dendritic spine; ISS:ParkinsonsUK-UCL
GO:0005783; C:endoplasmic reticulum; ISS:BHF-UCL
GO:0060076; C:excitatory synapse; IDA:BHF-UCL
GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:BHF-UCL
GO:0044224; C:juxtaparanode region of axon; IDA:MGI
GO:0044306; C:neuron projection terminus; ISS:BHF-UCL
GO:0044309; C:neuron spine; ISS:BHF-UCL
GO:0097481; C:neuronal postsynaptic density; IDA:BHF-UCL
GO:0014069; C:postsynaptic density; IDA:UniProtKB
GO:0045211; C:postsynaptic membrane; IDA:MGI
GO:0045202; C:synapse; IDA:MGI
GO:0008021; C:synaptic vesicle; ISS:BHF-UCL
GO:0033130; F:acetylcholine receptor binding; IDA:RGD
GO:0031697; F:beta-1 adrenergic receptor binding; IPI:UniProtKB
GO:0031748; F:D1 dopamine receptor binding; IPI:RGD
GO:0035254; F:glutamate receptor binding; IPI:BHF-UCL
GO:0035255; F:ionotropic glutamate receptor binding; IPI:RGD
GO:0031812; F:P2Y1 nucleotide receptor binding; IPI:BHF-UCL
GO:0030165; F:PDZ domain binding; IPI:RGD
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB
GO:0032403; F:protein complex binding; IPI:RGD
GO:0019901; F:protein kinase binding; IPI:RGD
GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL
GO:0005102; F:receptor binding; IPI:UniProtKB
GO:0097110; F:scaffold protein binding; ISS:BHF-UCL
GO:0097113; P:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering; IMP:BHF-UCL
GO:0060997; P:dendritic spine morphogenesis; IMP:BHF-UCL
GO:0045184; P:establishment of protein localization; ISS:BHF-UCL
GO:0035641; P:locomotory exploration behavior; ISS:BHF-UCL
GO:0002091; P:negative regulation of receptor internalization; IDA:UniProtKB
GO:0050885; P:neuromuscular process controlling balance; ISS:BHF-UCL
GO:0045161; P:neuronal ion channel clustering; TAS:UniProtKB
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IDA:BHF-UCL
GO:0050806; P:positive regulation of synaptic transmission; IDA:BHF-UCL
GO:0006461; P:protein complex assembly; ISS:BHF-UCL
GO:0035418; P:protein localization to synapse; IMP:BHF-UCL
GO:0097120; P:receptor localization to synapse; IMP:BHF-UCL
GO:2000821; P:regulation of grooming behavior; ISS:BHF-UCL
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; ISS:BHF-UCL
GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IDA:BHF-UCL
GO:0035176; P:social behavior; ISS:BHF-UCL
GO:0016188; P:synaptic vesicle maturation; ISS:BHF-UCL
GO:0071625; P:vocalization behavior; ISS:BHF-UCL

Interpro

InterPro; IPR016313; DLG1
InterPro; IPR008145; GK/Ca_channel_bsu
InterPro; IPR008144; Guanylate_kin-like
InterPro; IPR020590; Guanylate_kinase_CS
InterPro; IPR019590; MAGUK_PEST_N
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR001478; PDZ
InterPro; IPR019583; PDZ_assoc
InterPro; IPR011511; SH3_2
InterPro; IPR001452; SH3_domain

Pfam

Pfam; PF00625; Guanylate_kin;
Pfam; PF10608; MAGUK_N_PEST;
Pfam; PF00595; PDZ;
Pfam; PF10600; PDZ_assoc;
Pfam; PF07653; SH3_2;

SMART

SMART; SM00072; GuKc;
SMART; SM00228; PDZ;
SMART; SM00326; SH3;

PROSITE

PROSITE; PS00856; GUANYLATE_KINASE_1;
PROSITE; PS50052; GUANYLATE_KINASE_2;
PROSITE; PS50106; PDZ;
PROSITE; PS50002; SH3;

PRINTS